Evidence map›Paper›PMID 34561254›Full record

Observational studyBMJ open2021

Contribution of lung ultrasound in diagnosis of community-acquired pneumonia in the emergency department: a prospective multicentre study.

François Javaudin, Nicolas Marjanovic, Hugo de Carvalho, Benjamin Gaborit, Quentin Le Bastard, Estelle Boucher, Denis Haroche, Emmanuel Montassier, Philippe Le Conte

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03411824 (Lung Ultrasound for Community-acquired Pneumonia Diagnosis in Emergency Medicine), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03411824 completednot on this map

Lung Ultrasound for Community-acquired Pneumonia Diagnosis in Emergency Medicine

TypeobservationalSponsorNantes University HospitalRan2016 to 2019Enrolled90ConditionsCommunity Acquired PneumoniaArmsno intervention
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Guidelines for Antibiotics Prescription in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  7. Article
  8. Usefulness of thoracic ultrasound for diagnosis and follow-up of pneumonia.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

François JavaudinEmergency Department, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Nicolas MarjanovicDepartment of Emergency Medicine, CHU de Poitiers, Poitiers, France.
Hugo de CarvalhoDepartment of Emergency Medicine, Faculte de Medicine, Universite de Nantes, Nantes, France.ORCID 0000-0003-4101-695X
Benjamin GaboritDepartment of Infectious Diseases, Faculte de Medicine, University Hospital of Nantes and CIC 1413, INSERM, Nantes, France.
Quentin Le BastardDepartment of Emergency Medicine, Faculte de Medicine, Universite de Nantes, Nantes, France.
Estelle BoucherDepartment of Emergency Medicine, Hospital Center Saint Nazaire, Saint Nazaire, France.
Denis HarocheDepartment of Emergency Medicine, CHD Vendée, La Roche-sur-Yon, France.
Emmanuel MontassierEmergency Department, Centre Hospitalier Universitaire de Nantes, Nantes, France.ORCID 0000-0002-2313-1172
Philippe Le ConteEmergency Department, Centre Hospitalier Universitaire de Nantes, Nantes, France philippe.leconte@chu-nantes.fr.ORCID 0000-0002-3309-6112
Centre Hospitalier Universitaire de Nantes · FRNantes Université · FRCentre Hospitalier Saint-Nazaire · FRCentre Hospitalier Universitaire de Poitiers · FRInserm · FRRoche (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung ultrasound (LUS) can help clinicians make a timely diagnosis of community-acquired pneumonia (CAP).

objectivesTo assess if LUS can improve diagnosis and antibiotic initiation in emergency department (ED) patients with suspected CAP.

designA prospective observational study. SETTINGS: Four EDs.

participantsThe study included 150 patients older than 18 years with a clinical suspicion of CAP, of which 2 were subsequently excluded (incorrect identification), leaving 148 patients (70 women and 78 men, average age 72±18 years). Exclusion criteria included a life-threatening condition with do-not-resuscitate-order or patient requiring immediate intensive care.

interventionsAfter routine diagnostic procedure (clinical, radiological and laboratory tests), the attending emergency physician established a clinical CAP probability according to a four-level Likert scale (definite, probable, possible and excluded). An LUS was then performed, and another CAP probability was established based on the ultrasound result. An adjudication committee composed of three independent experts established the final CAP probability at hospital discharge. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary objective was to assess concordance rate of CAP diagnostic probabilities between routine diagnosis procedure or LUS and the final probability of the adjudication committee. Secondary objectives were to assess changes in CAP probability induced by LUS, and changes in antibiotic treatment initiation.

resultsOverall, 27% (95% CI 20 to 35) of the routine procedure CAP classifications and 77% (95% CI 71 to 84) of the LUS CAP classifications were concordant with the adjudication committee classifications. Cohen's kappa coefficients between routine diagnosis procedure and LUS, according to adjudication committee, were 0.07 (95% CI 0.04 to 0.11) and 0.61 (95% CI 0.55 to 0.66), respectively. The modified probabilities for the diagnosis of CAP after LUS resulted in changes in antibiotic prescriptions in 32% (95% CI 25 to 40) of the cases.

conclusionIn our study, LUS was a powerful tool to improve CAP diagnosis in the ED, reducing diagnostic uncertainty from 73% to 14%. TRIAL REGISTRATION NUMBER: NCT03411824.

Indexed as

Community-Acquired InfectionsPneumoniaAgedAged, 80 and overEmergency Service, HospitalFemaleHumansLungMaleMiddle AgedProspective StudiesUltrasonographyaccident & emergency medicineinfectious diseasesrespiratory infectionsultrasound

Identifiers

PMID34561254
PMCPMC8475146
OpenAlexW3200283884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.