ArticleDiabetes2021
CD8
Open access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen-Driven Autoimmunity.Immunological reviews · 2026Review
- Coxsackievirus B escapes antiviral CD8Science advances · 2026Article
- CD8Nature reviews. Cardiology · 2026Review
- Beyond bystanders: How β cell stress shapes the autoimmune response in T1D.Science translational medicine · 2026Review
- Neoepitopes at the crossroads of immunometabolism: metabolic remodeling of antigen presentation in type 1 diabetes.Frontiers in immunology · 2026Review
- A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes.Nature immunology · 2026Article
- Modulating immune response for the prevention and treatment of type 1 diabetes.Frontiers in immunology · 2026Review
- Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.Nature communications · 2025Article
- Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes.Frontiers in endocrinology · 2025Review
- The insulin secretory granule is a hotspot for autoantigen formation in type 1 diabetes.Diabetologia · 2024Review
- Immunogenicity of Non-Mutated Ovarian Cancer-Specific Antigens.Current oncology (Toronto, Ont.) · 2024Article
- Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8Science advances · 2024Article
- Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity.Journal for immunotherapy of cancer · 2023Article
- Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.bioRxiv : the preprint server for biology · 2023Article
- Human thymopoiesis produces polyspecific CD8eLife · 2023Article
- Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example.Seminars in immunology · 2023Review
- Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?Journal of personalized medicine · 2022Review
- Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.Frontiers in endocrinology · 2022Article
- Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 8 institutions in 5 countries.
Marie Eliane AzouryUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Fatoumata SamassaUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Mijke BuitingaLaboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Laura NigiToscana Life Sciences, Diabetes Unit and Fondazione Umberto di Mario ONLUS, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Noemi BruscoToscana Life Sciences, Diabetes Unit and Fondazione Umberto di Mario ONLUS, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Aïsha CallebautLaboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Matthieu GiraudCentre de Recherche en Transplantation et Immunologie, INSERM UMR1064, Université de Nantes, Nantes, France.
Magali IrlaCentre d'Immunologie de Marseille-Luminy, INSERM, CNRS, Aix-Marseille University, Marseille, France.
Ana Ines LalanneUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Alexia CarréUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Georgia AfonsoUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Zhicheng ZhouUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Barbara BrandaoUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Maikel L ColliMedical Faculty, Center for Diabetes Research and Welbio, Université Libre de Bruxelles, Brussels, Belgium.
Guido SebastianiToscana Life Sciences, Diabetes Unit and Fondazione Umberto di Mario ONLUS, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.ORCID 0000-0003-4374-8564
Francesco DottaToscana Life Sciences, Diabetes Unit and Fondazione Umberto di Mario ONLUS, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.ORCID 0000-0003-4947-7478
Maki NakayamaBarbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.
Decio L EizirikMedical Faculty, Center for Diabetes Research and Welbio, Université Libre de Bruxelles, Brussels, Belgium.ORCID 0000-0003-2453-5889
Sylvaine YouUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Sheena PintoDivision of Developmental Immunology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Mark J MamulaYale University School of Medicine, New Haven, CT.
Yann VerdierESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.
Joelle VinhESPCI Paris, PSL University, Spectrométrie de Masse Biologique et Protéomique, CNRS UMR8249, Paris, France.
Soren BuusDepartment of International Health, Immunology and Microbiology, Panum Institute, Copenhagen, Denmark.
Chantal MathieuLaboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Lut OverberghLaboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Roberto MalloneUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France roberto.mallone@inserm.fr.ORCID 0000-0002-9846-8861
Centre National de la Recherche Scientifique · FRKU Leuven · BEUniversity of Siena · ITUniversité Libre de Bruxelles · BEGerman Cancer Research Center · DEInserm · FRUniversity of Colorado Denver · USYale University · US
Funding
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MThe Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1MMultiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9MMolecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3MNIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK032083NIDDK NIH HHS R01 DK099317NIDDK NIH HHS U01 DK127786
Abstract
In type 1 diabetes, autoimmune β-cell destruction may be favored by neoantigens harboring posttranslational modifications (PTMs) such as citrullination. We studied the recognition of native and citrullinated glucose-regulated protein (GRP)78 peptides by CD8
Indexed as
AdolescentAdultAnimalsCD8-Positive T-LymphocytesChildCitrullinationDiabetes Mellitus, Type 1Endoplasmic Reticulum Chaperone BiPEpitopes, T-LymphocyteFemaleHumansLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred NODEndoplasmic Reticulum Chaperone BiPEpitopes, T-Lymphocyte
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.