Evidence map›Paper›PMID 34561087›Full record

ReviewThe Journal of investigative dermatology2021

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Lisa M Arkin, John J Moon, Jennifer M Tran, Samira Asgari, Cliona O'Farrelly, Jean-Laurent Casanova, Edward W Cowen, Jacqueline W Mays, Anne Marie Singh, Beth A Drolet and 1 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of investigative dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 12 institutions in 6 countries.

Lisa M ArkinDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
John J MoonDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jennifer M TranDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Samira AsgariDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Cliona O'FarrellyComparative Immunology, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, New York, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA.
Edward W CowenDermatology branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, USA.
Jacqueline W MaysOral Immunobiology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Anne Marie SinghDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Beth A DroletDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: bdrolet@dermatology.wisc.edu.
COVID Human Genetic Effort
University of Wisconsin–Madison · USInstitut des Maladies Génétiques Imagine · FRTrinity College Dublin · IEBrigham and Women's Hospital · USConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RUHelix (United States) · USInstitució Catalana de Recerca i Estudis Avançats · ESNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institutes of Health · USUniversité Claude Bernard Lyon 1 · FRVita-Salute San Raffaele University · IT

Funding

Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
Intramural NIH HHS ZIC DE000750
6 · The paper itself

Abstract

Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

Indexed as

AnimalsChilblainsCOVID-19HumansImmunity, InnateInterferon Type ISARS-CoV-2Interferon Type I

Identifiers

PMID34561087
PMCPMC8279931
OpenAlexW3179503992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.