Evidence map›Paper›PMID 34560869›Full record

Trial reportBMC musculoskeletal disorders2021

Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial.

Murillo Dório, Rosa Maria Rodrigues Pereira, Alexandre Galeno Branco Luz, Leticia Alle Deveza, Ricardo Manoel de Oliveira, Ricardo Fuller

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 16 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03138317 phase2unknown statusnot on this map

Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis

TypeinterventionalSponsorUniversity of Sao PauloRan2017 to 2018Enrolled60ConditionsOsteoarthritis, KneeArmsPRP, Plasma, Placebo
NCT07566039 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Cohort Study of Athletes Following an Injection of Platelet-Poor Plasma Into an Acute Muscle Injury

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2030Enrolled90ConditionsLower Extremity InjuryArmsPlatelet Poor Plasma (PPP) Injection
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 16 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Murillo DórioRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. murillodorio@gmail.com.
Rosa Maria Rodrigues PereiraRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Alexandre Galeno Branco LuzRDO Diagnósticos Médicos, São Paulo, Brazil.
Leticia Alle DevezaRheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.
Ricardo Manoel de OliveiraRDO Diagnósticos Médicos, São Paulo, Brazil.
Ricardo FullerRheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRCentrus Diagnósticos por Imagem · BRRoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatelet-rich plasma (PRP) has a still conflicting efficacy for knee osteoarthritis (KOA) and might be a minimally invasive and safe treatment alternative. The potential benefit of only plasma (non-enriched) has never been investigated. Our aim was to evaluate the efficacy of intra-articular platelet-rich plasma (PRP) and plasma to improve pain and function in participants with KOA over 24 weeks.

methodsRandomized, double-blind, placebo-controlled trial with 3 groups (n = 62): PRP (n = 20), plasma (n = 21) and saline (n = 21). Two ultrasound-guided knee injections were performed with a 2-week interval. The primary outcome was visual analog scale 0-10 cm (VAS) for overall pain at week 24, with intermediate assessments at weeks 6 and 12. Main secondary outcomes were: KOOS, OMERACT-OARSI criteria and TUGT.

resultsAt baseline, 92% of participants were female, with a mean age of 65 years, mean BMI of 28.0 Kg/m

conclusionsPRP and plasma were not superior to placebo for pain and function improvement in KOA over 24 weeks. The PRP group had a higher frequency of mild transitory increase in pain.

trial registrationClinicalTrials.gov, NCT03138317 , 03/05/2017.

Indexed as

Osteoarthritis, KneePlatelet-Rich PlasmaAgedDouble-Blind MethodFemaleHumansHyaluronic AcidInjections, Intra-ArticularMaleTreatment OutcomeHyaluronic AcidKnee osteoarthritisPlasmaPlatelet-rich plasmaPRP

Identifiers

PMID34560869
PMCPMC8461850
OpenAlexW3168403170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.