Evidence map›Paper›PMID 34560777›Full record

ArticleNeurosurgery2021

Systemic Immune-Inflammation Index Predicts Delayed Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

Joseph R Geraghty, Tyler J Lung, Yonatan Hirsch, Eitan A Katz, Tiffany Cheng, Neil S Saini, Dilip K Pandey, Fernando D Testai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 5 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joseph R GeraghtyDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-6828-4893
Tyler J LungDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Yonatan HirschDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Eitan A KatzDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Tiffany ChengDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Neil S SainiDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Dilip K PandeyDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Fernando D TestaiDepartment of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.
Illinois College · US

Funding

Targeting Neuroinflammation in Subarachnoid Hemorrhage-induced Epilepsy and Neurobehavioral ImpairmentF31NS105525 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GERAGHTY, JOSEPH RYAN · 2018 to 2020
$125k
NINDS NIH HHS 1F31NS105525-01A1NINDS NIH HHS F31 NS105525
6 · The paper itself

Abstract

backgroundDelayed cerebral vasospasm is a feared complication of aneurysmal subarachnoid hemorrhage (SAH).

objectiveTo investigate the relationship of systemic inflammation, measured using the systemic immune-inflammation (SII) index, with delayed angiographic or sonographic vasospasm. We hypothesize that early elevations in SII index serve as an independent predictor of vasospasm.

methodsWe retrospectively reviewed the medical records of 289 SAH patients for angiographic or sonographic evidence of delayed cerebral vasospasm. SII index [(neutrophils × platelets/lymphocytes)/1000] was calculated from laboratory data at admission and dichotomized based on whether or not the patient developed vasospasm. Multivariable logistic regression and receiver operating characteristic (ROC) analysis were performed to determine the ability of SII index to predict the development of vasospasm.

resultsA total of 246 patients were included in our study, of which 166 (67.5%) developed angiographic or sonographic evidence of cerebral vasospasm. Admission SII index was elevated for SAH in patients with vasospasm compared to those without (P < .001). In univariate logistic regression, leukocytes, neutrophils, lymphocytes, neutrophil-lymphocyte ratio (NLR), and SII index were associated with vasospasm. After adjustment for age, aneurysm location, diabetes mellitus, hyperlipidemia, and modified Fisher scale, SII index remained an independent predictor of vasospasm (odds ratio 1.386, P = .003). ROC analysis revealed that SII index accurately distinguished between patients who develop vasospasm vs those who do not (area under the curve = 0.767, P < .001).

conclusionEarly elevation in SII index can independently predict the development of delayed cerebral vasospasm in aneurysmal SAH.

Indexed as

Subarachnoid HemorrhageVasospasm, IntracranialHumansInflammationLymphocytesRetrospective StudiesAneurysmInflammationSubarachnoid hemorrhageSystemic immune-inflammation indexVasospasm

Identifiers

PMID34560777
PMCPMC8600162
OpenAlexW3200233341

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.