Evidence map›Paper›PMID 34560709›Full record

ArticleCancer nursing

Stability of Symptom Clusters in Patients With Gynecologic Cancer Receiving Chemotherapy.

Rachel A Pozzar, Marilyn J Hammer, Bruce A Cooper, Kord M Kober, Lee-May Chen, Steven M Paul, Yvette P Conley, Frances Cartwright, Fay Wright, Jon D Levine and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Review
  7. Article
  8. Article
  9. Article
  10. The change of symptom clusters in gastric cancer patients during the perioperative period: a longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  11. Article
  12. Article
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  14. Article
  15. Symptom burden survey and symptom clusters in patients with cervical cancer: a cross-sectional survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  16. Symptom clusters in outpatients with cancer using different dimensions of the symptom experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel A PozzarAuthor Affiliations: Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana-Farber Cancer Institute (Drs Pozzar and Hammer), Boston, Massachusetts; School of Nursing (Drs Cooper, Kober, Paul, and Miaskowski) and School of Medicine, University of California, San Francisco (Drs Chen, Levine, and Miaskowski); School of Nursing, University of Pittsburgh (Dr Conley), Pennsylvania; Mount Sinai Medical Center (Dr Cartwright), New York, New York; and Rory Myers College of Nursing, New York University (Dr Wright), New York.
Marilyn J Hammer
Bruce A Cooper
Kord M Kober
Lee-May Chen
Steven M Paul
Yvette P Conley
Frances Cartwright
Fay Wright
Jon D Levine
Christine Miaskowski

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
NCI NIH HHS R01 CA134900
6 · The paper itself

Abstract

backgroundPatients with gynecologic cancer undergoing chemotherapy experience multiple co-occurring symptoms. Understanding how symptom clusters change over time is essential to the development of interventions that target multiple co-occurring symptoms.

objectiveThe aim of this study was to assess the relative stability of symptom clusters across a chemotherapy cycle in patients with gynecologic cancer.

methodsThis is a longitudinal, descriptive study. Eligible patients (n = 232) were English-speaking adults (≥18 years old) with gynecologic cancer. Data were collected in the week before patients' second or third cycle of chemotherapy (T1) and at 1 (T2) and 2 (T3) weeks after chemotherapy. Three dimensions of the symptom experience (occurrence, severity, and distress) were assessed using a modified version of the Memorial Symptom Assessment Scale. Symptom clusters for each dimension and time point were identified through exploratory factor analysis.

resultsA 5-factor solution was selected for each exploratory factor analysis. Hormonal, respiratory, and weight change clusters were identified across all dimensions and time points. A psychological symptom cluster was identified at T1 for occurrence and severity and at T2 and T3 for all 3 dimensions. A gastrointestinal symptom cluster was identified at T1 for occurrence and at T2 and T3 for all 3 dimensions. The hormonal, respiratory, psychological, and weight change symptom clusters exhibited common symptoms across dimensions and time points.

conclusionsHormonal, respiratory, weight change, and psychological symptom clusters are relatively stable across a cycle of chemotherapy in patients with gynecologic cancer. IMPLICATIONS FOR PRACTICE: Clinicians need to assess patients for multiple co-occurring symptoms and initiate multimodal interventions.

Indexed as

Antineoplastic AgentsGenital Neoplasms, FemaleAdolescentAdultFactor Analysis, StatisticalFemaleHumansLongitudinal StudiesSyndromeAntineoplastic Agents

Identifiers

PMID34560709
PMCPMC8940749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.