Evidence map›Paper›PMID 34560292›Full record

ArticleRespiratory physiology & neurobiology2022

Magnetic twitch assessment of diaphragm and quadriceps weakness in critically ill mechanically ventilated patients.

Gerald S Supinski, Paul F Netzel, Philip M Westgate, Elizabeth A Schroder, Lin Wang, Leigh Ann Callahan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gerald S SupinskiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Paul F NetzelDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Philip M WestgateDepartment of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, United States.
Elizabeth A SchroderDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Lin WangDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Leigh Ann CallahanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, United States. Electronic address: lacall2@email.uky.edu.
University of Kentucky · US

Funding

Treatment of Skeletal Muscle Dysfunction in ICU PatientsR01HL113494 · NHLBI · UNIVERSITY OF KENTUCKY · PI SUPINSKI, GERALD S. · 2013 to 2016
$2.3M
Mitochondrially Targeted Therapies for Sepsis Induced Diaphragm DysfunctionR01HL141356 · NHLBI · UNIVERSITY OF KENTUCKY · PI CALLAHAN, LEIGH A, SCHRODER STUMPF, ELIZABETH A · 2018 to 2021
$2.2M
Respiratory Muscle WeaknessI01BX002132 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI SUPINSKI, GERALD S. · 2015 to 2018
–
BLRD VA I01 BX002132NHLBI NIH HHS R01 HL113494NHLBI NIH HHS R01 HL141356
6 · The paper itself

Abstract

Critically ill mechanically ventilated (MV) patients develop significant muscle weakness, which has major clinical consequences. There remains uncertainty, however, regarding the severity of leg weakness, the precise relationship between muscle strength and thickness, and the risk factors for weakness in MV patients. We therefore measured both diaphragm (PdiTw) and quadriceps (QuadTw) strength in MV patients using magnetic stimulation and compared strength to muscle thickness. Both PdiTw and QuadTw were profoundly reduced for MV patients, with PdiTw 19 % of normal and QuadTw 6% of normal values. There was a poor correlation between strength and thickness for both muscles, with thickness often remaining in the normal range when strength was severely reduced. Regression analysis revealed reductions in PdiTw correlated with presence of infection (p = 0.006) and age (p = 0.007). QuadTw best correlated with duration of MV (p = 0.036). Limb muscles are profoundly weak in critically ill patients, with a severity that mirrors the level of weakness observed in the diaphragm.

Indexed as

Critical IllnessRespiration, ArtificialAge FactorsDiaphragmHumansIntensive Care UnitsMagnetic FieldsMuscle WeaknessPhysical StimulationQuadriceps MuscleTime FactorsDiaphragm weaknessIntensive care unit myopathyMagnetic stimulationQuadriceps twitch force generationQuadriceps weaknessTransdiaphragmatic pressure generation

Identifiers

PMID34560292
PMCPMC8604769
OpenAlexW3199656058

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.