ArticleMolecular cell2021
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
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Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Microautophagy: current understanding of its molecular mechanisms and functions.Autophagy reports · 2026Review
- PMA exerts anti-leukemia effect in PhCancer cell international · 2025Article
- T-lymphocytes suppression by CD14Journal of translational medicine · 2025Article
- Mutation Analysis of TMB-High Colorectal Cancer: Insights Into Molecular Pathways and Clinical Implications.Cancer science · 2025Article
- Autoinducer-2 enhances the defense ofmBio · 2025Article
- FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma.Theranostics · 2025Article
- Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma.Molecular cell · 2024Article
- Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer.Nature communications · 2024Article
- PKCActa pharmaceutica Sinica. B · 2024Article
- Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.Developmental cell · 2024Article
- Physiological functions of ULK1/2.Journal of molecular biology · 2024Review
- Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.Signal transduction and targeted therapy · 2024Article
- TBK1 is paradoxical in tumor development: a focus on the pathway mediating IFN-I expression.Frontiers in immunology · 2024Review
- Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.Nature communications · 2023Article
- The emerging mechanisms and functions of microautophagy.Nature reviews. Molecular cell biology · 2023Review
- Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.Cancer cell · 2023Article
- Protein kinase Cλ/ι in cancer: a contextual balance of time and signals.Trends in cell biology · 2022Review
- Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer.Cancers · 2022Review
- Chaperone-Mediated Autophagy in Pericytes: A Key Target for the Development of New Treatments against Glioblastoma Progression.International journal of molecular sciences · 2022Review
- Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.Nature communications · 2022Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Juan F LinaresDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Xiao ZhangDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Anxo Martinez-OrdoñezDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Angeles DuranDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Hiroto KinoshitaDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Hiroaki KasashimaDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City 545-8585, Japan.
Naoko NakanishiDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yuki NakanishiDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ryan CarelliDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Luca CappelliDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Esperanza AriasDepartments of Medicine and of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Masakazu YashiroDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City 545-8585, Japan.
Masaichi OhiraDepartment of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City 545-8585, Japan.
Sanjay PatelDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Giorgio InghiramiDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Massimo LodaDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Ana Maria CuervoDepartments of Medicine and of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maria T Diaz-MecoDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: mtd4001@med.cornell.edu.
Jorge MoscatDepartment of Pathology and Laboratory Medicine and Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: jom4010@med.cornell.edu.
Cornell University · USOsaka City University · JPAlbert Einstein College of Medicine · USKyoto Prefectural University of Medicine · JPKyoto University · JP
Funding
Weill Cornell Medicine (WCM) SPORE in Prostate CancerP50CA211024 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUDAS, LORRAINE J · 2017 to 2021
$10.9MControl of vesicular trafficking in the hepatocyte.R01DK098408 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA, WOLKOFF, ALLAN W · 2013 to 2022
$5.6MDecreased Protein Degradation in AgingR37AG021904 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2013 to 2022
$4.4MRole of p62 in metabolic reprograming of the tumor stroma in prostate cancerR01CA218254 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DIAZ MECO CONDE, MARIA TERESA, METALLO, CHRISTIAN MICHAEL · 2017 to 2021
$2.6MMolecular mechanisms driving mesenchymal colorectal cancerR01CA250025 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCAT, JORGE · 2021 to 2025
$2.2MMechanisms of cell death and autophagy in intestinal epithelial cells in inflammation and cancerR01CA207177 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCAT, JORGE · 2017 to 2021
$2.1MRole of CMA failure in NASH progression to Hepatocellular CarcinomaR01DK124308 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ARIAS-PEREZ, ESPERANZA · 2020 to 2023
$1.5MNCI NIH HHS P50 CA211024NCI NIH HHS R01 CA207177NCI NIH HHS R01 CA218254NCI NIH HHS R01 CA250025NIA NIH HHS R37 AG021904NIDDK NIH HHS R01 DK098408NIDDK NIH HHS R01 DK124308
Abstract
The interferon (IFN) pathway is critical for cytotoxic T cell activation, which is central to tumor immunosurveillance and successful immunotherapy. We demonstrate here that PKCλ/ι inactivation results in the hyper-stimulation of the IFN cascade and the enhanced recruitment of CD8
Indexed as
Signal TransductionAdultAgedAged, 80 and overAnimalsAutophagyCarcinogenesisCD8-Positive T-LymphocytesCell Transformation, NeoplasticColorectal NeoplasmsCycloheximideFemaleHEK293 CellsHumansImmunophenotypingInterferon Regulatory Factor-3CycloheximideInterferon Regulatory Factor-3InterferonsIRF3 protein, humanIsoenzymesMembrane ProteinsProtein Kinase CProtein Kinase C-lambdaProtein Serine-Threonine KinasesSTING1 protein, humanSTING ProteinTBK1 protein, humanTranscription FactorsUlk2 protein, humanUlk2 protein, mouseatypical PKCautophagychaperone-mediated autophagycolorectal cancerimmunosuppressionimmunosurveillanceimmunotherapyinterferonSTINGULK1/2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.