ArticleCNS neuroscience & therapeutics2022
Identification of embolic stroke in patients with large vessel occlusion: The Chinese embolic stroke score, CHESS.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 7 citations in OpenAlex.
- Tmax Mismatch Ratio to Identify Intracranial Atherosclerotic Stenosis-Related Large-Vessel Occlusion Before Endovascular Therapy.Journal of the American Heart Association · 2023Trial
- A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score.CNS neuroscience & therapeutics · 2026Article
- Outcomes of mechanical thrombectomy in acute stroke due to primary embolic middle cerebral artery M2 occlusions: a comparison of late versus early windows.Therapeutic advances in neurological disorders · 2026Article
- Prevalence, clinical characteristics, and outcomes of carotid web in Chinese patients with acute ischemic stroke due to intracranial large vessel occlusion.Quantitative imaging in medicine and surgery · 2025Article
- CT perfusion for predicting intracranial atherosclerotic middle cerebral artery occlusion.Frontiers in neurology · 2024Article
- Elevated pulsatility index is associated with poor functional outcome in stroke patients treated with thrombectomy: A retrospective cohort study.CNS neuroscience & therapeutics · 2022Article
- Identification of embolic stroke in patients with large vessel occlusion: The Chinese embolic stroke score, CHESS.CNS neuroscience & therapeutics · 2022Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of the study was to develop a simple and objective score using clinical variables and quantified perfusion measures to identify embolic stroke with large vessel occlusions.
methodsEligible patients from five centers participating in the International Stroke Perfusion Imaging Registry were included in this study. Patients were split into a derivation cohort (n = 213) and a validation cohort (n = 116). A score was developed according to the coefficients of independent predictors of embolic stroke from stepwise logistic regression model in the derivation cohort. The performance of the score was validated by assessing its discrimination and calibration.
resultsThe independent predictors of embolic stroke made up the Chinese Embolic Stroke Score (CHESS). There were: history of atrial fibrillation (3 points), non-hypertension history (2 points), and delay time>6 s volume/delay time>3 s volume on perfusion imaging ≥0.23 (2 points). The AUC of CHESS in the derivation cohort and validation cohort were 0.87 and 0.79, respectively. Patients with a CHESS of 0 could be identified as low-risk of embolic stroke, with a CHESS of 2-4 could be identified as medium-risk and with a CHESS of 5-7 could be regarded as high-risk. The observed rate of embolic stroke of each risk group was well-calibrated with the predicted rate.
conclusionCHESS could reliably and independently identify embolic stroke as the cause of large vessel occlusion.
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