ArticleMedicine and science in sports and exercise2022
Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases.
Article in Medicine and science in sports and exercise, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Evaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.Scandinavian journal of medicine & science in sports · 2026Article
- Genetic, lifestyle and environmental influences on health: a Finnish biobank recall study protocol (BioRecall).BMJ open · 2026Article
- Associations of smoking status and leisure-time physical activity with waist circumference change-10-year follow-up among twin adults.International journal of obesity (2005) · 2025Article
- Genetic Liability to Higher Muscle Strength Associates With a Lower Risk of Cardiovascular Disease Mortality in Men Irrespective of Leisure-Time Physical Activity in Adulthood: A Longitudinal Cohort Study.Journal of the American Heart Association · 2025Article
- Polygenic risk analysis in physical activity and health: why are the same results interpreted differently?British journal of sports medicine · 2025Article
- Genetic associations with temporal trends in physical activity and body mass index across four decades: the population-based HUNT study, Norway.BMJ open sport & exercise medicine · 2025Article
- The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.European journal of epidemiology · 2025Article
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality: Findings from the Finnish Twin Cohort.Medicine and science in sports and exercise · 2024Article
- Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Dose-response associations, physical activity intensity and mortality risk: A narrative review.Journal of sport and health science · 2024Review
- Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study.European journal of epidemiology · 2023Article
- Article
- Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity.Scandinavian journal of medicine & science in sports · 2022Review
- Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers: A Controlled Study.Metabolites · 2022Article
- Can genetics guide exercise prescriptions in osteoarthritis?Frontiers in rehabilitation sciences · 2022Article
- Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences.Frontiers in molecular biosciences · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGenetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRS) and cardiometabolic diseases among the Finnish population.
methodsPRS for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genomewide genotyping and extensive digital longitudinal health register data. Associations between PA PRS and body mass index, diseases, and mortality were analyzed with linear and logistic regression models.
resultsA high PA PRS predicted a lower body mass index (β = -0.025 kg·m-2 per one SD change in PA PRS, SE = 0.013, P = 1.87 × 10-80). The PA PRS also predicted a lower risk for diseases that typically develop later in life or not at all among highly active individuals. A lower disease risk was systematically observed for cardiovascular diseases (odds ratio [OR] per 1 SD change in PA PRS = 0.95, P = 9.5 × 10-19) and, for example, hypertension [OR = 0.93, P = 2.7 × 10-44), type 2 diabetes (OR = 0.91, P = 4.1 × 10-42), and coronary heart disease (OR = 0.95, P = 1.2 × 10-9). Participants with high PA PRS had also lower mortality risk (OR = 0.97, P = 0.0003).
conclusionsGenetically less active persons are at a higher risk of developing cardiometabolic diseases, which may partly explain the previously observed associations between low PA and higher disease and mortality risk. The same inherited physical fitness and metabolism-related mechanisms may be associated both with PA levels and with cardiometabolic disease risk.
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