Evidence map›Paper›PMID 34559578›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Ubiquitin ligase

Laura B Snyder, Yimu Lai, Heather Doviak, Lisa A Freeburg, Valerie K Laney, Amber Moore, Kia N Zellars, Lydia E Matesic, Francis G Spinale

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Novel Therapeutic Avenues for Hypertrophic Cardiomyopathy.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023
    Review
  6. Article
  7. Calpains as Potential Therapeutic Targets for Myocardial Hypertrophy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Laura B SnyderCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Yimu LaiCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Heather DoviakCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Lisa A FreeburgCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Valerie K LaneyCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Amber MooreCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Kia N ZellarsCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.
Lydia E MatesicDepartment of Biological Sciences, University of South Carolina, Columbia, South Carolina.
Francis G SpinaleCell Biology and Anatomy, University of South Carolina School of Medicine and Columbia Veterans Affairs Health Care System, Columbia, South Carolina.ORCID 0000-0003-0529-5605
University of South Carolina · US

Funding

Intracellular Sorting of Connexin 43 by the Ubiquitin Ligase Wwp1R01HL104030 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MATESIC, LYDIA ELEANOR · 2010 to 2014
$1.7M
NHLBI NIH HHS R01 HL104030
6 · The paper itself

Abstract

Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E

Indexed as

Ventricular Function, LeftVentricular RemodelingAnimalsAortaDiastoleDisease Models, AnimalDisease ProgressionExtracellular MatrixFemaleFibrillar CollagensGene DeletionHeart FailureHeart VentriclesHypertrophy, Left VentricularMaleMiceFibrillar CollagensUbiquitin-Protein LigasesWWP1 protein, mousecardiac hypertrophydiastolic dysfunctionheart failureubiquitin ligase WWP1ventricular remodeling

Identifiers

PMID34559578
PMCPMC12080916
OpenAlexW3199475134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.