Evidence map›Paper›PMID 34559564›Full record

ArticleScience advances2021

Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor.

Marie Saitou, Skyler Resendez, Apoorva J Pradhan, Fuguo Wu, Natasha C Lie, Nancy J Hall, Qihui Zhu, Laura Reinholdt, Yoko Satta, Leo Speidel and 7 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Predicting Archaic Hominin Phenotypes from Genomic Data.Annual review of genomics and human genetics · 2022
    Review
  12. Article
  13. Article
  14. Association of thePakistan journal of medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marie SaitouDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-8794-3217
Skyler ResendezDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-0422-2335
Apoorva J PradhanDepartment of Chemistry, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-3884-0676
Fuguo WuDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-6266-5647
Natasha C LieDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Nancy J HallDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-4828-8106
Qihui ZhuThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0003-2401-8443
Laura ReinholdtThe Jackson Laboratory, Bar Harbor, ME, USA.
Yoko SattaDepartment of Evolutionary Studies of Biosystems, SOKENDAI (Graduate University for Advanced Studies), Kanagawa Prefecture, Japan.
Leo SpeidelUniversity College London, Genetics Institute, London, UK.
Shigeki NakagomeSchool of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-9613-975X
Neil A HanchardDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-1925-2665
Gary ChurchillThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0001-9190-9284
Charles LeeThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID 0000-0001-7317-6662
G Ekin Atilla-GokcumenDepartment of Chemistry, University at Buffalo, Buffalo, NY, USA.
Xiuqian MuDepartment of Ophthalmology, Ross Eye Institute, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0002-8003-7529
Omer GokcumenDepartment of Biological Sciences, University at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-4371-679X

Funding

Translational CoreP30AG038070 · NIA · JACKSON LABORATORY · PI Gary A Churchill · 2010 to 2026
$19.3M
Regulatory mechanisms for retinal ganglion cell genesisR01EY020545 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Xiuqian Mu · 2011 to 2026
$5.7M
Regulation of mRNA decay in retinal development and maintenanceR01EY029705 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MU, XIUQIAN · 2020 to 2023
$2.0M
NEI NIH HHS R01 EY020545NEI NIH HHS R01 EY029705NIA NIH HHS P30 AG038070Wellcome Trust
6 · The paper itself

Abstract

The common deletion of the third exon of the growth hormone receptor gene (

Identifiers

PMID34559564
PMCPMC8462886

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.