ArticleScience advances2021
Cell activity modulation and its specific function maintenance by bioinspired electromechanical nanogenerator.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Motion-driven piezoelectric response in self-powered hydrogel nanofibers enhances wound healing via intermediate filament remodeling and modulation of energy metabolism.Journal of advanced research · 2026Article
- Oral Motion-Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Electroactive microneedle augmented stem cell therapy in myocardial infarction.Science advances · 2026Article
- A bioabsorbable body-coupling-electrotherapy suture.Nature communications · 2025Article
- Bioinspired micro-structured fibers for biomedical applications.Bioactive materials · 2025Review
- Article
- Piezoelectric Heterojunctions as Bacteria-Killing Bone-Regenerative Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A bioabsorbable mechanoelectric fiber as electrical stimulation suture.Nature communications · 2024Article
- Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure.Science advances · 2024Article
- Advances in Bioresorbable Triboelectric Nanogenerators.Chemical reviews · 2023Review
- Non-electric bioelectrical analog strategy by a biophysical-driven nano-micro spatial anisotropic scaffold for regulating stem cell niche and tissue regeneration in a neuronal therapy.Bioactive materials · 2023Article
- Electrospun Conducting Polymers: Approaches and Applications.Materials (Basel, Switzerland) · 2022Review
- Biofeedback electrostimulation for bionic and long-lasting neural modulation.Nature communications · 2022Article
- Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration.Research (Washington, D.C.) · 2022Review
- What can AI-TENG do for Low Abundance Biosensing?Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biophysical characteristics of the extracellular matrix (ECM), such as a three-dimensional (3D) network and bioelectricity, have a profound influence on cell development, migration, function expression, etc. Here, inspired by these biophysical cues of ECM, we develop an electromechanical coupling bio-nanogenerator (bio-NG) composed of highly discrete piezoelectric fibers. It can generate surface piezopotential up to millivolts by cell inherent force and thus provide in situ electrical stimulation for the living cells. Besides, the unique 3D space in the bio-NGs provides an ECM-like growth microenvironment for cells. As a result, our bio-NGs effectively promote cell viability and development and, more importantly, maintain its specific functional expression. These advanced in vitro bio-NGs are expected to fill the gap between the inaccurate 2D systems and the expensive and time-consuming animal models, mimicking the complexity of the ECM and the physiological relevance of an in vivo biological system.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.