Evidence map›Paper›PMID 34559500›Full record

SynthesisBiomedica : revista del Instituto Nacional de Salud2021

Sarcopenia and blood albumin: A systematic review with meta-analysis

Jack Roberto Silva-Fhon, Violeta Magdalena Rojas-Huayta, Juan Pablo Aparco-Balboa, Bernardo Céspedes-Panduro, Rosalina Aparecida Partezani-Rodrigues

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Biomedica : revista del Instituto Nacional de Salud, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Risk Factors of Sarcopenia in COPD Patients: A Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jack Roberto Silva-FhonEscola de Enfermagem, Universidade de São Paulo, São Paulo, Brasil; Centro Brasileiro para o Cuidado à Saúde Baseado em Evidências: Centro de Evidência do JBI, São Paulo, Brasil. betofhon@usp.br.
Violeta Magdalena Rojas-HuaytaNúcleo de Investigación en Alimentación y Nutrición Pública, Escuela de Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. vrojashu@unmsm.edu.pe.
Juan Pablo Aparco-BalboaNúcleo de Investigación en Alimentación y Nutrición Pública, Escuela de Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. jp_aparco@hotmail.com.
Bernardo Céspedes-PanduroNúcleo de Investigación en Alimentación y Nutrición Pública, Escuela de Nutrición, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú; Escuela de Estadística, Facultad de Matemáticas, Universidad Nacional Mayor de San Marcos, Lima, Perú; Facultad de Estudios Generales, Universidad Privada del Norte, Lima, Perú. bcespedesp@unmsm.edu.pe.
Rosalina Aparecida Partezani-RodriguesEscola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brasil. rosalina@eerp.usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is characterized by loss of muscle mass during aging, which can have consequences for the individuals’ health. There are many ways to detect it, among them, with the use of blood biomarkers such as albumin, although the association between the two has not been confirmed yet. This review synthesizes the knowledge on the association between sarcopenia and serum albumin among elderly individuals through a systematic review and meta-analysis focused on the etiology and risk factors. We used the Joanna Briggs Institute software for the review and conducted a search in MEDLINE, Embase, CINAHL, and LILACS databases while two reviewers conducted an independent manual search. EpiDat, version 3.1 was used for the meta-analysis; mean differences with the albumin scores disaggregated by sarcopenia were analyzed by the random-effects model. The degree of heterogeneity was assessed with the DerSimonian and Laird Q test. We analyzed 630 articles and finally included 14 in the review. Higher blood albumin levels were found in the meta-analysis, which was statistically significant among the elderly adults who did not present sarcopenia compared to those who did. Although there are studies exploring the association between albumin and sarcopenia, there is a need to continue evaluating its association with biological markers and comparing them to verify which can be used to detect sarcopenia among the elderly.

Indexed as

SarcopeniaAgedAgingHumansRisk FactorsSerum AlbuminSerum AlbuminAgedAgingAlbuminsBiomarkersMeta-analysisSarcopeniaSystematic review

Identifiers

PMID34559500
PMCPMC8527986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.