Trial reportAdvances in therapy2021
Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase 1 Trial.
Trial report in Advances in therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Median Effective Concentration of Ciprofol and Its Correlation With Bispectral Index: A Prospective Observational Study
A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Ciprofol versus propofol and the risk of hemodynamic adverse events: a meta-analysis with trial sequential analysis of randomized controlled trials.BMC anesthesiology · 2026Pooled it
- Efficacy and safety of ciprofol versus propofol for anesthesia in patients undergoing gastrointestinal endoscope: a systematic review and meta-analysis of randomized controlled trials (RCT).BMC anesthesiology · 2025Pooled it
- A meta-analysis and systematic review based on perioperative management of elderly patients: is ciprofol an alternative to propofol?European journal of clinical pharmacology · 2025Pooled it
- Ciprofol versus propofol for sedation in colonoscopy: a systematic review and meta-analysis of randomized controlled trials.Brazilian journal of anesthesiology (Elsevier)Pooled it
- Long-Term Sedation Effect of Cipepofol Compared to Dexmedetomidine in Patients Receiving Invasive Mechanical Ventilation: A Multicenter, Randomized, Open-Label, Parallel-Controlled Study.Advances in therapy · 2026Trial
- Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- A Comparative Study of Pharmacokinetics and Pharmacodynamics of Continuous Ciprofol Infusion Between Young and Elderly Patients.Drug design, development and therapy · 2026Trial
- Comparison of the Safety and Efficacy of CiprofolCurrent medicinal chemistry · 2026Trial
- Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Effects of Cipepofol on Cardiac Depolarization and Repolarization in Healthy Subjects: A Single-Center, Randomized, Placebo and Positive-Controlled Thorough QT Study.Drug design, development and therapy · 2026Trial
- Ciprofol versus propofol for long-term sedation in mechanically ventilated patients with sepsis: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Effective dose of ciprofol combined with low-dose sufentanil for sedation of gastroscopy: a dose-finding study using a biased coin design.BMC anesthesiology · 2025Trial
- Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients.BMC anesthesiology · 2025Trial
- Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation.Scientific reports · 2025Trial
- Study on the effective dose of alfentanil combined with ciprofol in inhibiting intraoperative body movement responses in patients undergoing breast lump resection.Frontiers in medicine · 2025Trial
- The Recovery of Ciprofol, Remimazolam and Remimazolam-Flumazenil for General Anesthesia Undergoing Fundus Surgery: A Single-Center, Prospective, Randomized, Controlled Clinical Study.Drug design, development and therapy · 2025Trial
- Generic Intravenous Amisulpride (QLG2069) for the Prevention of Postoperative Nausea and Vomiting in Adults: A Phase III, Multicenter, Randomized, Placebo-Controlled Study.Drug design, development and therapy · 2025Trial
- Effects of Ciprofol on Hemodynamics During Induction in Hypertensive Patients: A Prospective, Randomized, Double-Blind, Controlled Study.Drug design, development and therapy · 2025Trial
- The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation: a study using up-and-down sequential allocation method.BMC anesthesiology · 2024Trial
- Effect of Lidocaine on Ciprofol Dosage and Efficacy in Patients Who Underwent Gastroscopy Sedation.Medical science monitor basic research · 2024Trial
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe effects of continuous infusions of ciprofol on its pharmacodynamic and pharmacokinetic properties and safety profiles in healthy Chinese subjects were evaluated.
methodsIn this open-label, randomized, two-way cross-over study, subjects received initial doses of continuous ciprofol/propofol as an infusion for 30 min in part 1 (n = 8) and a bolus dose in part 2 (n = 8) followed by maintenance infusions for a total of 4 h in part 1 and 12 h in part 2. Each subject participated in both parts with a washout time of at least 40 h.
resultsThe safety and tolerability parameters of ciprofol were similar to those of propofol, and all treatment-emergent adverse events were mild. The incidences of injection pain and respiratory depression in subjects given ciprofol were lower than those receiving propofol. The pharmacokinetic parameters C
conclusionCiprofol has potential for clinical application for continuous intravenous infusion to maintain sedation for 12 h with the same safety, tolerability and efficacy as propofol.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.