Observational studyInternational journal of colorectal disease2022
An evaluation of short-term outcomes after reoperations for anastomotic leakage in colon cancer patients.
Observational study in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Indocyanine Green Fluorescence Imaging for Colorectal Surgery: A Health Technology Assessment.Ontario health technology assessment series · 2025Pooled it
- Risk Factors for Anastomotic Leaks in Simultaneous Resection of Primary Colon Cancer with Synchronous Liver Metastasis: A NSQIP Study.Annals of surgical oncology · 2026Article
- Perioperative splanchnic perfusion variation around colorectal surgery using both indocyanine green spectrophotometry and fluorescence angiography.Surgical endoscopy · 2026Article
- A landmark-based dynamic prediction model for anastomotic leakage after rectal cancer surgery: integrating perioperative and postoperative trajectories.Frontiers in oncology · 2026Article
- Risk factors for anastomotic leakage and long-term outcomes after laparoscopic right colectomy: a multicenter study in a Japanese rural area.Surgery today · 2025Article
- Stoma associated complications after diverting loop ileostomy, end ileostomy or split stoma formation after right sided colectomy-a retrospective cohort study (StoComSplit Analysis).Techniques in coloproctology · 2024Article
- Impact of anastomotic leakage on long-term prognosis after colorectal cancer surgery.World journal of gastrointestinal surgery · 2023Review
- Impacts of trans-anal tube placement in patients with sigmoid colon cancer: Risk verification analysis using inverse probability weighting analysis.Annals of gastroenterological surgery · 2023Article
- The usefulness of indocyanine green fluorescence imaging for intestinal perfusion assessment of intracorporeal anastomosis in laparoscopic colon cancer surgery.International journal of colorectal disease · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeScarce data are available on differences among index colectomies for colon cancer regarding reoperation for anastomotic leakage (AL) and clinical consequences. Therefore, this nationwide observational study aimed to evaluate reoperations for AL after colon cancer surgery and short-term postoperative outcomes for the different index colectomies.
methodsPatients who underwent resection with anastomosis for a first primary colon carcinoma between 2013 and 2019 and were registered in the Dutch ColoRectal Audit were included. Primary outcomes were mortality, ICU admission, and stoma creation.
resultsAmong 39,565 patients, the overall AL rate was 4.8% and ranged between 4.0% (right hemicolectomy) and 15.4% (subtotal colectomy). AL was predominantly managed with reoperation, ranging from 81.2% after transversectomy to 92.4% after sigmoid resection (p < 0.001). Median time to reoperation differed significantly between index colectomies (range 4-8 days, p < 0.001), with longer and comparable intervals for non-surgical reinterventions (range 13-18 days, p = 0.747). After reoperation, the highest mortality rates were observed for index transversectomy (15.4%) and right hemicolectomy (14.4%) and lowest for index sigmoid resection (5.6%) and subtotal colectomy (5.9%) (p < 0.001). Reoperation with stoma construction was associated with a higher mortality risk than without stoma construction after index right hemicolectomy (17.7% vs. 8.5%, p = 0.001). ICU admission rate was 62.6% overall (range 56.7-69.2%), and stoma construction rate ranged between 65.5% (right hemicolectomy) and 93.0% (sigmoid resection).
conclusionSignificant differences in AL rate, reoperation rate, time to reoperation, postoperative mortality after reoperation, and stoma construction for AL were found among the different index colectomies for colon cancer, with relevance for patient counseling and perioperative management.
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