SynthesisEnvironmental health perspectives2021
Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature.
Synthesis in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A State of the Science Review of Wildfire-Specific Fine Particulate Matter Data Sources, Methods, and Models.Environmental health perspectives · 2025Pooled it
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Ambient air pollution and clinical dementia: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Is Greenness Associated with Dementia? A Systematic Review and Dose-Response Meta-analysis.Current environmental health reports · 2022Pooled it
- Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Precision residential greenspace, urban environmental exposures, and incident dementia among older adults in Sweden: A 16-year cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The association between PMEnvironmental research · 2026Article
- A critical review of potential modifiers of air pollutant associations with dementia and related outcomes.Neurotoxicology · 2026Review
- Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mediation role of estimated pulse wave velocity in the association between physical activity and cognitive function.Medicine · 2026Article
- Leveraging Dissolved Organic Matter Collections as a Natural Chemical Library to Link Molecular Traits with Cellular Morphological Responses.Environmental science & technology · 2026Article
- Spatial and spectral mapping of traffic-related nanoparticles in hippocampal subregions of an Alzheimer disease model.Environmental pollution (Barking, Essex : 1987) · 2026Article
- Occupational autonomy and cognitive function: the moderating role of educational attainment.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Is memory in older adulthood influenced by changes in air pollution over the previous decade?: Examining concurrent trajectories in ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026Article
- Accounting for Exposure Measurement Error in Gridded Air Pollution Estimates in Assessing the Association of PMEnvironmental science & technology · 2026Article
- Associations of PMThe Journal of international medical research · 2026Article
- Personalised estimation of exposure to ambient air pollution and application in a longitudinal cohort analysis of cognitive function in London-dwelling older adults.Journal of exposure science & environmental epidemiology · 2026Article
- Dissecting the effect of long-term exposure to air pollution on risk of dementia in UK Biobank.Environmental health : a global access science source · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDementia is a devastating neurologic condition that is common in older adults. We previously reviewed the epidemiological evidence examining the hypothesis that long-term exposure to air pollution affects dementia risk. Since then, the evidence base has expanded rapidly.
objectivesWith this update, we collectively review new and previously identified epidemiological studies on air pollution and late-life cognitive health, highlighting new developments and critically discussing the merits of the evidence.
methodsUsing a registered protocol (PROSPERO 2020 CRD42020152943), we updated our literature review to capture studies published through 31 December 2020, extracted data, and conducted a bias assessment.
resultsWe identified 66 papers (49 new) for inclusion in this review. Cognitive level remained the most commonly considered outcome, and particulate matter (PM) remained the most commonly considered air pollutant. Since our prior review, exposure estimation methods in this research have improved, and more papers have looked at cognitive change, neuroimaging, and incident cognitive impairment/dementia, though methodological concerns remain common. Many studies continue to rely on administrative records to ascertain dementia, have high potential for selection bias, and adjust for putative mediating factors in primary models. A subset of 35 studies met strict quality criteria. Although high-quality studies of fine particulate matter with aerodynamic diameter DISCUSSION: Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.