ArticleHepatology communications2022
Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population.
Article in Hepatology communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
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Who cites it
229 citing papers in PubMed, 369 citations in OpenAlex.
- Article
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- MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease.Nature communications · 2026Article
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- Association between remnant cholesterol and cardiometabolic multimorbidity in non-alcoholic fatty liver disease patients: evidence from a cross-sectional study.BMC gastroenterology · 2026Article
- Joint effects of sleep duration and sleep difficulty on suicidal ideation: evidence from NHANES 2005-2018.BMC psychiatry · 2026Article
- Elevated body roundness index and epilepsy prevalence: a cross-sectional study.Scientific reports · 2026Article
- Associations of folic acid supplements and dietary folate intake with gestational diabetes mellitus: complementary evidence from a multimethod investigation.Frontiers in nutrition · 2026Article
- Diet quality assessed by healthy eating index and its association with metabolic aging: mediation by systemic immune-inflammation index.Frontiers in nutrition · 2026Article
- Diabetes modifies the cross-sectional association between Healthy Eating Index-2015 and clinically relevant depressive symptoms: a NHANES analysis with an independent hospital-based replication cohort.Frontiers in nutrition · 2026Article
- The Mediating Role of WBC in the Relationship Between Triglyceride-Glucose Index and Chronic Pain: Evidence From NHANES 2001-2004 Data.Pain research & management · 2026Article
169 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Physiologic aging leads to attrition of telomeres and replicative senescence. An acceleration of this process has been hypothesized in the progression of chronic liver disease. We sought to examine the association of telomere length (TL) with liver disease and its impact on mortality risk. A cohort of 7,072 adults with leukocyte TL measurements from the National Health and Nutrition Examination Survey 1999-2002 with mortality follow-up through 2015 was analyzed. Liver disease was defined by aminotransferase levels and classified into etiology-based and advanced fibrosis categories. Multivariable-adjusted linear regression models estimated effect sizes, with 95% confidence intervals (CIs), of the presence of liver disease on TL. Cox regression models evaluated associations between TL and all-cause mortality risk using adjusted hazard ratios (HRs). The cohort was representative of the US population with mean age 46.1 years and mean TL 5.79 kilobase pairs. No overall association between TL and liver disease was found; however, there was a significant negative association of TL and advanced liver fibrosis in individuals aged 65 and above. The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) and those with metabolic syndrome (HR 1.26, 95% CI 0.96-1.67) had increased mortality risk with shorter TL. The relationship between TL and all-cause mortality was stronger in women (HR 1.51, 95% CI 1.02-2.23) and in non-Hispanic Whites (HR 1.37, 95% CI 1.02-1.84). Conclusion: Shortened leukocyte TL is independently associated with advanced liver disease at older ages, and with a higher risk of all-cause mortality in those with liver disease. These associations reaffirm the need to better understand the role of telomeres in the progression of liver disease.
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