Evidence map›Paper›PMID 34558817›Full record

ArticleHepatology communications2021

Nonalcoholic Fatty Liver Disease Prevalence Trends Among Adolescents and Young Adults in the United States, 2007-2016.

Tamoore Arshad, James M Paik, Rakesh Biswas, Saleh A Alqahtani, Linda Henry, Zobair M Younossi

Abstract read
In one paragraph

Article in Hepatology communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  18. Commentary on Kehar et al.Canadian liver journal · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tamoore ArshadCenter for Liver DiseaseDepartment of MedicineInova Fairfax Medical CampusFalls ChurchVAUSA.
James M PaikBetty and Guy Beatty Center for Integrated ResearchInova Health SystemFalls ChurchVAUSA.
Rakesh BiswasCenter for Liver DiseaseDepartment of MedicineInova Fairfax Medical CampusFalls ChurchVAUSA.
Saleh A AlqahtaniJohns Hopkins UniversityBaltimoreMDUSA.
Linda HenryCenter for Outcomes Research in Liver DiseaseWashingtonDCUSA.
Zobair M YounossiCenter for Liver DiseaseDepartment of MedicineInova Fairfax Medical CampusFalls ChurchVAUSA.ORCID 0000-0001-9313-577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the burden of NAFLD among adolescents and young adults has become increasingly relevant. Our aim was to estimate the prevalence of NAFLD among adolescents and young adults in the United States. Data were obtained from National Health and Nutrition Examination Survey from 2007-2016. Adolescents and young adults aged 12 to 29 years were included. NAFLD was determined by the U.S. Fatty Liver Index in the absence of secondary causes of liver disease, and the differences in prevalence trends were analyzed based on age, gender, and race. Complete data were available for 4,654 adolescents and young adults (mean age 21 years; 50.9% male; 56.8% White, 20.9% Hispanic, and 13.3% Black). The overall prevalence of NAFLD among adolescents and young adults was 18.5%, ranging from 13.2% among early and middle adolescents (12-17 years) to 18.7% among late adolescents and young adults (18-24 years), to 24.0% among older young adults (25-30 years) (trend P < 0.001). The prevalence of NAFLD was higher for boys than for girls (aged 12-17: 15.1% vs. 11.3%; aged 18-24: 21.1% vs. 16.2%; aged 25-30: 28.7% vs. 19.2%, all P < 0.030). Among all age groups, Hispanics had a higher prevalence of NAFLD than Whites and Blacks (pairwise P < 0.001). Over the study time period, the prevalence of NAFLD among early and middle adolescents and young adults did not change (trend P > 0.80). In contrast, NAFLD prevalence among late adolescents increased (trend P = 0.018). In fact, White and Hispanic late adolescents were the drivers behind this increase in the prevalence of NAFLD. Conclusion: These data indicate an increasing trend in NAFLD prevalence among 18-24-year-olds. These data have important public health and policy implications.

Indexed as

AdolescentAdultBlack or African AmericanBlack PeopleChildFemaleHispanic or LatinoHumansMaleNon-alcoholic Fatty Liver DiseaseNutrition SurveysPopulation HealthPrevalenceUnited StatesWhite PeopleYoung Adult

Identifiers

PMID34558817
PMCPMC8485885

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.