ArticleThe Kaohsiung journal of medical sciences2022
Association of Internet gaming disorder with catechol-O-methyltransferase: Role of impulsivity and fun-seeking.
Article in The Kaohsiung journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- A case-control study for psychiatric comorbidity and associative factors of gaming disorder and hazardous gaming based on ICD-11 criteria: Cognitive control, emotion regulation, and reinforcement sensitivity.Journal of behavioral addictions · 2024Article
- Online Sexual Risk Behaviors in Adolescents: Roles of Family Relationships, Impulsivity, and Attention-Deficit/Hyperactivity Disorder.Children (Basel, Switzerland) · 2024Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions.Journal of behavioral addictions · 2023Review
- Neurobiological risk factors for problematic social media use as a specific form of Internet addiction: A narrative review.World journal of psychiatry · 2023Review
- Prevalence of Common Alleles of Some Stress Resilience Genes among Adolescents Born in Different Periods Relative to the Socioeconomic Crisis of the 1990s in Russia.Current issues in molecular biology · 2022Article
- Association of Internet gaming disorder with catechol-O-methyltransferase: Role of impulsivity and fun-seeking.The Kaohsiung journal of medical sciences · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Dopamine functioning is an essential mechanism underlying addictive behaviors. This paper evaluates the association of Internet gaming disorder (IGD) with the catechol-O-methyltransferase (COMT) val158met polymorphism and examines the roles of impulsivity and reinforcement sensitivity in this association. Using diagnostic interviews, this study recruited 69 participants with IGD and 138 participants without. All participants underwent diagnostic interviews for IGD and an evaluation for the COMT val158met polymorphism, impulsivity, and reinforcement sensitivity. Among participants with the Val/Val genotype, the odds ratio (95% confidence interval) for IGD was 2.09 (1.15-3.80). The IGD-Val/Val genotype association was mediated by impulsivity and fun-seeking. The Val/Val genotype is indicative of low frontal functioning and is a predictive factor of IGD, with this effect being confounded by impulsivity and fun-seeking. Interventions targeting impulsivity and fun-seeking might attenuate the risk of IGD, particularly among individuals with the Val/Val genotype. Additional studies are necessary to elucidate the possible role of dopamine functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.