Evidence map›Paper›PMID 34558671›Full record

ArticleComprehensive Physiology2021

Working Memory: From Neural Activity to the Sentient Mind.

Russell J Jaffe, Christos Constantinidis

Open access · greenAbstract read
In one paragraph

Article in Comprehensive Physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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  4. Asynchronous firing and off-states in working memory maintenance.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
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  7. Review
  8. Article
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  11. [Effects of 50 Hz electromagnetic field on rat working memory and investigation of neural mechanisms].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Strong Gamma Frequency Oscillations in the Adolescent Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Russell J JaffeDepartment of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Christos ConstantinidisDepartment of Neurobiology & Anatomy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Vanderbilt University Medical Center · USWake Forest University · US

Funding

NEUROPHYSIOLOGICAL EFFECTS OF TRAINING IN VISUAL COGNITIVE TASKSR01EY017077 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHRISTOS CONSTANTINIDIS · 2006 to 2026
$6.0M
Neurophysiology of Working Memory Maturation in AdolescenceR01MH116675 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS, WHITLOW, CHRISTOPHER T · 2018 to 2022
$2.4M
NEI NIH HHS R01 EY017077NIMH NIH HHS R01 MH116675
6 · The paper itself

Abstract

Working memory (WM) is the ability to maintain and manipulate information in the conscious mind over a timescale of seconds. This ability is thought to be maintained through the persistent discharges of neurons in a network of brain areas centered on the prefrontal cortex, as evidenced by neurophysiological recordings in nonhuman primates, though both the localization and the neural basis of WM has been a matter of debate in recent years. Neural correlates of WM are evident in species other than primates, including rodents and corvids. A specialized network of excitatory and inhibitory neurons, aided by neuromodulatory influences of dopamine, is critical for the maintenance of neuronal activity. Limitations in WM capacity and duration, as well as its enhancement during development, can be attributed to properties of neural activity and circuits. Changes in these factors can be observed through training-induced improvements and in pathological impairments. WM thus provides a prototypical cognitive function whose properties can be tied to the spiking activity of brain neurons. © 2021 American Physiological Society. Compr Physiol 11:1-41, 2021.

Indexed as

Memory, Short-TermPrefrontal CortexAnimalsBrainCognitionNeurons

Identifiers

PMID34558671
PMCPMC8573634
OpenAlexW3201511938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.