ArticleThe American journal of clinical nutrition2022
A proinflammatory diet is associated with increased odds of frailty after 12-year follow-up in a cohort of adults.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study.European journal of medical research · 2024Pooled it
- Trial
- Article
- Nutrition literacy, dietary diversity, and frailty among older adults in China.BMC geriatrics · 2026Article
- Dietary Inflammatory Index and cardiometabolic and inflammatory profiles in children and adolescents with type 1 diabetes: a cross-sectional study.Pediatric research · 2026Article
- Association between dietary inflammation index and frailty among community medical staff.Frontiers in nutrition · 2026Article
- Can malnutrition, dietary habits, and diet quality be determinant factors in frailty, sarcopenia, low physical function, and depression in older adults?BMC geriatrics · 2025Article
- Ultra-Processed Food and Frailty: Evidence from a Prospective Cohort Study and Implications for Future Research.Nutrients · 2025Article
- Berries and Steps: a protocol of a randomized, placebo-controlled pilot study testing freeze-dried blueberry powder in sedentary older adults with mild depressive symptoms.Nutrition journal · 2025Article
- Nutrition and dietary inflammatory indices of the eight major cuisines of China.BMC nutrition · 2025Article
- Association of dietary inflammatory index, composite dietary antioxidant index, and frailty in elderly adults with diabetes.European journal of medical research · 2024Article
- Socio-demographic differences in the dietary inflammatory index from National Health and Nutrition Examination Survey 2005-2018: a comparison of multiple imputation versus complete case analysis.Public health nutrition · 2024Article
- Article
- Dietary inflammatory index, mediating biomarkers and incident frailty in Chinese community-dwelling older adults.The journal of nutrition, health & aging · 2024Article
- Diet quality from mid to late life and its association with physical frailty in late life in a cohort of Chinese adults.Nutrition journal · 2024Article
- Dietary inflammatory index, dietary total antioxidant capacity, and frailty among older Chinese adults.The journal of nutrition, health & aging · 2024Article
- Impact of the anti-inflammatory diet on serum high-sensitivity C-Reactive protein and new-onset frailty in community-dwelling older adults: A 7-year follow-up of the Kashiwa cohort study.Geriatrics & gerontology international · 2024Article
- Performance of FRAX in older adults with frailty: the Framingham Heart Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Demographic risk factors of pro-inflammatory diet: a narrative review.Frontiers in nutrition · 2024Review
- Understanding the Causes of Frailty Using a Life-Course Perspective: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
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10 authors.
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Abstract
backgroundFrailty occurs in 10-15% of community-living older adults and inflammation is a key determinant of frailty. Though diet is a modulator of inflammation, there are few prospective studies elucidating the role of diet-associated inflammation on frailty onset.
objectivesWe sought to determine whether a proinflammatory diet was associated with increased odds of frailty in adults from the Framingham Heart Study (FHS). DESIGN AND
methodsThis study was nested in a prospective cohort that included individuals without frailty. Diet was assessed in 1998-2001 using a valid FFQ, and frailty was measured in 2011-2014. FFQ-derived energy-adjusted dietary inflammatory index (E-DII®) scores were computed, with higher E-DII scores indicating a more proinflammatory diet. Frailty was defined as fulfilling ≥3 of 5 Fried Phenotype criteria. Information on potential mediators, serum IL-6 and C-reactive protein was obtained in 1998-2001. Logistic regression estimated ORs and 95% CIs for E-DII (as continuous and in quartiles) and frailty onset adjusting for relevant confounders.
resultsOf 1701 individuals without frailty at baseline (mean ± SD age: 58 ± 8 y; range: 33-81 y; 55% female), 224 developed frailty (13% incidence) over ∼12 y. The mean ± SD E-DII score was -1.95 ± 2.20; range: -6.71 to +5.40. After adjusting for relevant confounders, a 1-unit higher E-DII score was associated with 16% increased odds of developing frailty (95% CI: 1.07, 1.25). In categorical analyses, participants in the highest (proinflammatory) compared with lowest quartile of E-DII had >2-fold increased odds of frailty (ORquartile4vs.1: 2.22; 95% CI: 1.37, 3.60; P-trend < 0.01). IL-6 and C-reactive protein were not major contributors in the pathway.
conclusionsIn this cohort of middle-aged and older adults, a proinflammatory diet was associated with increased odds of frailty over ∼12 y of follow-up. Trials designed to increase consumption of anti-inflammatory foods for frailty prevention are warranted.
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