Evidence map›Paper›PMID 34558320›Full record

ArticleGlobal spine journal2023

Titanium Cervical Cage Subsidence: Postoperative Computed Tomography Analysis Defining Incidence and Associated Risk Factors.

Zachariah W Pinter, Ryder Reed, Sarah E Townsley, Anthony L Mikula, Lauren Dittman, Ashley Xiong, Jonathan Skjaerlund, Giorgos D Michalopoulos, Bradford Currier, Ahmad Nassr and 7 more

Open access · goldAbstract read
In one paragraph

Article in Global spine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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  3. Answer to the letter to the editor of A. Abudayeh, et al. concerning "Lateral lumbar interbody fusion with lateral plating: techniques, feasibility and efficacy" by T. Siu, et al. (Eur Spine J [2025]; doi:10.1007/s00586-025-09411-w).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Zachariah W PinterDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3011-0991
Ryder ReedDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Sarah E TownsleyDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Anthony L MikulaDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Lauren DittmanDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Ashley XiongDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Jonathan SkjaerlundDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Giorgos D MichalopoulosDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Bradford CurrierDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Ahmad NassrDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Jeremy L FogelsonDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Brett A FreedmanDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3408-0163
Mohamad BydonDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-0543-396X
Christopher K KeplerDepartment of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Scott C WagnerDepartment of Orthopedic Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Benjamin D ElderDepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
Arjun S SebastianDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USMayo Clinic · USThomas Jefferson University · USWalter Reed National Military Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designRetrospective cohort study.

objectiveSubstantial variability in both the measurement and classification of subsidence limits the strength of conclusions that can be drawn from previous studies. The purpose of this study was to precisely characterize patterns of cervical cage subsidence utilizing computed tomography (CT) scans, determine risk factors for cervical cage subsidence, and investigate the impact of subsidence on pseudarthrosis rates.

methodsWe performed a retrospective review of patients who underwent one- to three-levels of anterior cervical discectomy and fusion (ACDF) utilizing titanium interbodies with anterior plating between the years 2018 and 2020. Subsidence measurements were performed by two independent reviewers on CT scans obtained 6 months postoperatively. Subsidence was then classified as mild if subsidence into the inferior and superior endplate were both ≤2 mm, moderate if the worst subsidence into the inferior or superior endplate was between 2 to 4 mm, or severe if the worst subsidence into the inferior or superior endplate was ≥4 mm.

resultsA total of 51 patients (100 levels) were included in this study. A total of 48 levels demonstrated mild subsidence (≤2 mm), 38 demonstrated moderate subsidence (2-4 mm), and 14 demonstrated severe subsidence (≥4 mm). Risk factors for severe subsidence included male gender, multilevel constructs, greater mean vertebral height loss, increased cage height, lower Taillard index, and lower screw tip to vertebral body height ratio. Severe subsidence was not associated with an increased rate of pseudarthrosis.

conclusionFollowing ACDF with titanium cervical cages, subsidence is an anticipated postoperative occurrence and is not associated with an increased risk of pseudarthrosis.

Indexed as

anterior cervical discectomy and fusioncomputed tomographyinterbodypseudarthrosisrisk factorssubsidencetitanium cage

Identifiers

PMID34558320
PMCPMC10556899
OpenAlexW3201002116

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.