Evidence map›Paper›PMID 34558218›Full record

ArticlePhysiological reports2021

The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.

Mani Sadredini, Ravinea Manotheepan, Stephan E Lehnart, Mark E Anderson, Ivar Sjaastad, Mathis K Stokke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Mani SadrediniInstitute for Experimental Medical Research and KG Jebsen Cardiac Research Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.
Ravinea ManotheepanInstitute for Experimental Medical Research and KG Jebsen Cardiac Research Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.
Stephan E LehnartHeart Research Center Göttingen, Department of Cardiology and Pulmonology, University Medical Center Göttingen, Georg August University Göttingen, Göttingen, Germany.
Mark E AndersonDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, USA.
Ivar SjaastadInstitute for Experimental Medical Research and KG Jebsen Cardiac Research Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.
Mathis K StokkeInstitute for Experimental Medical Research and KG Jebsen Cardiac Research Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.ORCID 0000-0002-8869-8153
Oslo University Hospital · NOJohns Hopkins University · USUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β-adrenoceptor stimulation-induced diastolic Ca

Indexed as

MutationAdrenergic beta-1 Receptor AgonistsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingFemaleMaleMiceMice, Inbred C57BLMyocytes, CardiacOxidantsOxidation-ReductionRyanodine Receptor Calcium Release ChannelTachycardia, VentricularAdrenergic beta-1 Receptor AgonistsCalcium-Calmodulin-Dependent Protein Kinase Type 2Oxidantsryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelarrhythmiasCaMKIICPVToxidationRyR2

Identifiers

PMID34558218
PMCPMC8461029
OpenAlexW3200232587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.