Evidence map›Paper›PMID 34557980›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2021

Circulating trace elements for the prediction of preeclampsia and small for gestational age babies.

Daniel R McKeating, Joshua J Fisher, Teresa MacDonald, Sue Walker, Stephen Tong, William W Bennett, Tu'uhevaha J Kaitu'u-Lino, Anthony V Perkins

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
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  7. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel R McKeatingSchool of Medical Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia.
Joshua J FisherHunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Teresa MacDonaldTranslational Obstetrics Group, Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia.
Sue WalkerTranslational Obstetrics Group, Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia.
Stephen TongTranslational Obstetrics Group, Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia.
William W BennettSchool of Environment, Griffith University, Gold Coast Campus, Southport, QLD, Australia.
Tu'uhevaha J Kaitu'u-LinoTranslational Obstetrics Group, Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, VIC, Australia.
Anthony V PerkinsSchool of Medical Science, Griffith University, Gold Coast Campus, Parklands Drive, Southport, QLD, 4215, Australia. a.perkins@griffith.edu.au.ORCID 0000-0002-9829-6772
Mercy Hospital for Women · AUGriffith University · AUHunter Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPoor gestational outcomes due to placental insufficiency can have lifelong consequences for mother and child.

objectiveThere is a need for better methods of diagnosis, and elemental metabolomics may provide a means to determine the risk of gestational disorders.

methodsThis study used blood plasma samples collected at 36 weeks' gestation from women who later developed preeclampsia (n = 38), or small-for-gestational age babies (n = 91), along with matched controls (n = 193). Multi-element analysis was conducted by inductively coupled plasma mass spectrometer (ICP-MS), allowing simultaneous measurement of 28 elements.

resultsWomen who later developed PE, exhibited significantly increased concentrations of K, Rb and Ba. For SGA pregnancies, there was a significant increase in Cu and a decrease in As concentrations. Despite significant differences in single elements, the elemental profile of groups indicated no clustering of control, PE, or SGA samples. Positive predicative values correctly identified approximately 60% of SGA and 70% of PE samples.

conclusionThis is the first-time elemental metabolomics has been used to predict SGA and PE at 36 weeks. Though significant changes were identified, routine clinical use may be limited but may contribute to a multi marker test. Future analysis should include other biomarkers, metabolic data or clinical measurements made throughout gestation.

Indexed as

Pre-EclampsiaTrace ElementsBiomarkersChildFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgePlacentaPregnancyBiomarkersTrace ElementsPreeclampsiaPregnancySmall for gestational ageTrace elements

Identifiers

PMID34557980
OpenAlexW3200008756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.