Evidence map›Paper›PMID 34557968›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Neurophysiological and ultrasonographic comparative study of autonomous nervous system in patients suffering from fibromyalgia and generalized anxiety disorder.

Marianna Papadopoulou, Apostolos Papapostolou, Eleni Bakola, Vasilios G Masdrakis, Christos Moschovos, Elisabeth Chroni, Georgios Tsivgoulis, Ioannis Michopoulos

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. RDoC Mechanisms Underlying Bodily Symptoms in Psychiatry: A Scoping Review.Psychology research and behavior management · 2026
    Review
  4. Article
  5. Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing.Open access rheumatology : research and reviews · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Sustained Enlargement in Vagus and Sural Nerve Cross-Sectional Areas in Fibromyalgia: A Longitudinal Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marianna PapadopoulouSecond Department of Neurology, Medical School, National and Kapodistrian University of Athens Attikon University General Hospital, Athens, Greece. marpapgr@yahoo.co.uk.ORCID http://orcid.org/0000-0002-0163-7455
Apostolos PapapostolouPrivate Practice, Athens, Greece.
Eleni BakolaSecond Department of Neurology, Medical School, National and Kapodistrian University of Athens Attikon University General Hospital, Athens, Greece.
Vasilios G MasdrakisFirst Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.
Christos MoschovosSecond Department of Neurology, Medical School, National and Kapodistrian University of Athens Attikon University General Hospital, Athens, Greece.
Elisabeth ChroniDepartment of Neurology, School of Medicine, University of Patras, Rio-Patras, Greece.
Georgios TsivgoulisSecond Department of Neurology, Medical School, National and Kapodistrian University of Athens Attikon University General Hospital, Athens, Greece.
Ioannis MichopoulosSecond Department of Psychiatry, Medical School, National and Kapodistrian University of Athens, Attikon University General Hospital, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibromyalgia (FM) and generalized anxiety disorder (GAD) share common clinical features: they both affect women more than men, their diagnosis is based solely on clinical criteria, and some of the symptoms such as anxiety, aches and muscle tension, sleep disorders, and cognitive dysfunction occur in both diseases. For both conditions, an underlying dysregulation of the autonomic nervous system (ANS) has been proposed.

objectiveThe aims of this study were to investigate ANS dysfunction in FM and GAD and compare them with controls.

methodsSympathetic skin response (SSR) from palm and sole and cross-sectional area (CSA) of bilateral vagus nerves (VN) were measured in 28 healthy controls, 21 FM patients, and 24 GAD patients.

resultsCSA of VN was significantly smaller in FM patients (right: 1.97 ± 0.74mm

conclusionThis study confirms similar ANS abnormalities in FM and GAD that fairly distinguish them from controls and support the hypothesis of a common pathophysiological substrate underlying both conditions.

Indexed as

FibromyalgiaAnxiety DisordersAutonomic Nervous SystemFemaleHumansMalePainVagus NerveCross-sectional areaFibromyalgiaGeneralized anxiety disorderSympathetic skin responseVagus nerve

Identifiers

PMID34557968
OpenAlexW3200654931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.