Evidence map›Paper›PMID 34557892›Full record

ArticleJournal of biochemistry2022

Human TRPV1 and TRPA1 are receptors for bacterial quorum sensing molecules.

Naoya Tobita, Kana Tsuneto, Shigeaki Ito, Takeshi Yamamoto

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  2. Article
  3. Review
  4. Mitochondria: great balls of fire.The FEBS journal · 2024
    Review
  5. Article
  6. TRPV1: The key bridge in neuroimmune interactions.Journal of intensive medicine · 2024
    Review
  7. TRPA1 InfluencesInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Naoya Tobita
Kana Tsuneto
Shigeaki Ito
Takeshi Yamamoto
Japan Tobacco (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the activation of TRPV1 and TRPA1 by N-acyl homoserine lactones, quorum sensing molecules produced by Gram-negative bacteria, and the inhibitory effect of TRPV1 and TRPA1 by autoinducing peptides (AIPs), quorum sensing molecules produced by Gram-positive bacteria, using human embryonic kidney 293T cell lines stably expressing human TRPV1 and TRPA1, respectively. As a result, we found that some N-acyl homoserine lactones, such as N-octanoyl-L-homoserine lactone (C8-HSL), N-nonanoyl-L-homoserine lactone (C9-HSL) and N-decanoyl-L-homoserine lactone (C10-HSL), activated both TRPV1 and TRPA1. In addition, we clarified that some N-acyl homoserine lactones, such as N-3-oxo-dodecanoyl-L-homoserine lactone (3-oxo-C12-HSL), only activated TRPV1 and N-acyl homoserine lactones having saturated short acyl chain, such as N-acetyl-L-homoserine lactone (C2-HSL) and N-butyryl-L-homoserine lactone (C4-HSL), only activated TRPA1. Furthermore, we found that an AIP, simple linear peptide CHWPR, inhibited both TRPV1 and TRPA1 and peptide having thiolactone ring DICNAYF, the thiolactone ring were formed between C3 to F7, strongly inhibited only the TRPV1. Although the specificity of TRPV1 and TRPA1 for quorum sensing molecules was different, these data suggest that both TRPV1 and TRPA1 would function as receptors for quorum sensing molecule produced by bacteria. Graphical Abstract.

Indexed as

Quorum SensingAcyl-ButyrolactonesGram-Negative BacteriaHEK293 CellsHumansTRPA1 Cation ChannelTRPV Cation ChannelsAcyl-ButyrolactonesTRPA1 Cation ChannelTRPA1 protein, humanTRPV1 protein, humanTRPV Cation ChannelsAbbreviations:AHL; N-acyl homoserine lactone; AhR; aryl hydrocarbon receptor; AIP; autoinducing peptide; HSL; homoserine lactone; IL; interleukin; [Ca2+]i; intracellular Ca2+ concentration; IQGAP1; IQ-motif-containing GTPase-activating protein; LPS; lipopolysaccharide; PPAR; peroxisome proliferator activated receptor; T2R; taste receptor type 2; TRPA1; transient receptor potential cation channel; subfamily A; member 1; TRPM3; transient receptor potential cation channel; subfamily M; member 3; TRPM8; transient receptor potential cation channel; subfamily M; member 8; TRPV1; transient receptor potential cation channel; subfamily V; member 1; TRPV2; transient receptor potential cation channel; subfamily V; member 2; TRPV4; transient receptor potential cation channel; subfamily V; member 4; C2-HSL; N-acetyl-L-homoserine lactone; C4-HSL; N-butyryl-L-homoserine lactone; C6-HSL; N-hexanoyl-L-homoserine lactone; C7-HSL; N-heptanoyl-L-homoserine lactone; C8-HSL; N-octanoyl-L-homoserine lactone; C9-HSL; N-nonanoyl-L-homoserine lactone; C10-HSL; N-decanoyl-L-homoserine lactone; C11-HSL; N-undecanoyl-L-homoserine lactone; C12-HSL; N-dodecanoyl-L-homoserine lactone; C13-HSL; N-tridecanoyl-L-homoserine lactone; C14-HSL; N-tetradecanoyl-L-homoserine lactone; C15-HSL; N-pentadecanoyl-L-homoserine lactone; C16-HSL; N-hexadecanoyl-L-Homoserine lactone; 3-oxo-C6-HSL; N-(β-ketocaproyl)-L-homoserine lactone; 3-oxo-C8-HSL; N-3-oxo-octanoyl-L-homoserine lactone; 3-oxo-C10-HSL; N-3-oxo-decanoyl-L-homoserine lactone; 3-oxo-C12-HSL; N-3-oxo-dodecanoyl-L-homoserine lactone; 3-oxo-C14-HSL; N-3-oxo-tetradecanoyl-L-homoserine lactone; 3-oxo-C16-HSL; N-3-oxo-hexadecanoyl-L-homoserine lactone; OH-C8-HSL; N-3-hydroxyoctanoyl-L-homoserine lactone; OH-C10-HSL; N-3-hydroxydecanoyl-L-homoserine lactone; C14:1-Δ9-cis-HSL; N-cis-tetradec-9Z-enoyl-L-homoserine lactone; C16:1-Δ9-cis-HSL; N-cis-hexadec-9Z-enoyl-L-homoserine lactone; C18:1-Δ9-cis-HSL; N-cis-octadec-9Z-enoyl-L-homoserine lactone; 3-oxo-C14:1-Δ7-cis-HSL; N-3-oxo-tetradec-7(Z)-enoyl-L-homoserine lactone; 3-oxo-C16:1-Δ11-cis-HSL; N-3-oxo-hexadec-11(Z)-enoyl-L-homoserine lactoneautoinducing peptidesN-acyl homoserine lactonesquorum sensing moleculesTRPA1TRPV1

Identifiers

PMID34557892
OpenAlexW3199492015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.