Evidence map›Paper›PMID 34557863›Full record

ArticleCell reports methods2021

Highly efficient manipulation of nervous system gene expression with NEPTUNE.

Katrin Mangold, Jan Mašek, Jingyan He, Urban Lendahl, Elaine Fuchs, Emma R Andersson

Open access · goldAbstract read
In one paragraph

Article in Cell reports methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using in utero transduction.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Clonal Tracking in the Mouse Brain with Single-Cell RNA-Seq.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Katrin MangoldDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Jan MašekDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge 14183, Sweden.
Jingyan HeDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Urban LendahlDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Elaine FuchsLaboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Emma R AnderssonDepartment of Cell and Molecular Biology, Karolinska Institutet, Stockholm 17177, Sweden.
Karolinska Institutet · SEHoward Hughes Medical Institute · US

Funding

GENE EXPRESSION AND DIFFERENTIATION IN HUMAN EPIDERMISR37AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI ELAINE FUCHS · 1994 to 2026
$13.3M
Skin Stem Cells: Purification and CharacterizationR01AR050452 · NIAMS · ROCKEFELLER UNIVERSITY · PI ELAINE FUCHS · 2004 to 2026
$8.6M
GENE EXPRESSION &DIFFERENTIATION IN HUMAN EPIDERMISR01AR027883 · NIAMS · UNIVERSITY OF CHICAGO · PI FUCHS, ELAINE · 1986 to 2022
$7.6M
NIAMS NIH HHS R01 AR027883NIAMS NIH HHS R01 AR050452NIAMS NIH HHS R37 AR027883
6 · The paper itself

Abstract

Genetic loss and gain of function in mice have typically been studied by using knockout or knockin mice that take months to years to generate. To address this problem for the nervous system, we developed NEPTUNE (NEural Plate Targeting by

Indexed as

NeptuneNeural Tube DefectsAnimalsBrainGene ExpressionMiceNeural Tube

Identifiers

PMID34557863
PMCPMC8457050
OpenAlexW3178724821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.