Evidence map›Paper›PMID 34557840›Full record

ArticleThe Lancet regional health. Europe2021

Decade-long trends in surgery for acute Type A aortic dissection in England: A retrospective cohort study.

Umberto Benedetto, Shubhra Sinha, Arnaldo Dimagli, Graham Cooper, Giovanni Mariscalco, Rakesh Uppal, Narain Moorjani, George Krasopoulos, Amit Kaura, Mark Field and 6 more

Abstract read
In one paragraph

Article in The Lancet regional health. Europe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
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  7. Article
  8. Early clinical outcomes in emergency CABG in the United Kingdom.Frontiers in cardiovascular medicine · 2026
    Article
  9. Aortic dissection mortality in the United States, 1968-2023: Trends, disparities, and deep learning forecasts.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
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  15. A machine learning algorithm-based risk prediction score for in-hospital/30-day mortality after adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Article
  16. Review
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  19. Article
  20. Management of acute aortic dissection in critical care.Journal of the Intensive Care Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Umberto BenedettoBristol Heart Institute, Translational Health Sciences, University of Bristol, UK.
Shubhra SinhaBristol Heart Institute, Translational Health Sciences, University of Bristol, UK.
Arnaldo DimagliBristol Heart Institute, Translational Health Sciences, University of Bristol, UK.
Graham CooperNorthern General Hospital, Sheffield, UK.
Giovanni MariscalcoGlenfield Hospital, University of Leicester, UK.
Rakesh UppalSt. Bartholomew's Hospital, London, UK.
Narain MoorjaniRoyal Papworth Hospital, Cambridge, UK.
George KrasopoulosOxford Heart Centre, John Radcliffe Hospital, UK.
Amit KauraNIHR Imperial Biomedical Research Centre, Imperial College London and Imperial College Healthcare NHS Trust, Hammersmith Hospital, London W12 0HS, UK.
Mark FieldDepartment of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.
Uday TrivediRoyal Sussex County Hospital, Brighton, UK.
Simon KendallThe James Cook University Hospital, Middlesbrough, UK.
Gianni D AngeliniBristol Heart Institute, Translational Health Sciences, University of Bristol, UK.
Enoch F AkowuahThe James Cook University Hospital, Middlesbrough, UK.
Geoffrey TsangSouthampton General Hospital, Southampton, UK.
UK Aortic Group

Funding

British Heart Foundation CH/1992027/7163
6 · The paper itself

Abstract

backgroundLittle is known about variations in care and outcomes of patients undergoing surgical repair for type A aortic dissection(TAAD). We aim to investigate decade-long trends in TAAD surgical repair in England.

methodsRetrospective review of the National Adult Cardiac Surgery Audit, which prospectively collects demographic and peri‑operative information for all major adult cardiac surgery procedures performed in the UK. We identified patients undergoing surgery for TAAD from January 2009-December 2018, reviewed trends in operative frequency, patient demographics, and mortality.

findingsOver the 10-year period,3,680 TAAD patients underwent surgical repair in England. A doubling in the overall number of operations conducted in England was observed (235 cases in 2009 to 510 in 2018). Number of procedures per hospital per year also doubled(9 in 2009 to 23 in 2018). Overall, in-hospital mortality was 17.4% with a trend toward lower mortality in recent years(23% in 2009 to 14.7% in 2018). There was a significant variation in operative mortality between hospitals and surgeons. We also found that most patients presented towards the middle of the week and during winter.

interpretationSurgery is the only treatment for acute TAAD but is associated with high mortality. Prompt diagnosis and referral to a specialist center is paramount. The number of operations conducted in England has doubled in 10 years and the associated survival has improved. Variations exist in service provision with a trend towards better survival in high volume centers.

fundingBritish Heart Foundation and NIHR Biomedical Research center(University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol).

Identifiers

PMID34557840
PMCPMC8454541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.