Evidence map›Paper›PMID 34557666›Full record

ArticleBrain communications2021

Immunopathogenesis and proposed clinical score for identifying Kelch-like protein-11 encephalitis.

Alberto Vogrig, Sarah Péricart, Anne-Laurie Pinto, Véronique Rogemond, Sergio Muñiz-Castrillo, Géraldine Picard, Marion Selton, Michel Mittelbronn, Hélène-Marie Lanoiselée, Patrick Michenet and 11 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Paraneoplastic Neurologic Syndromes Associated With Merkel Cell Carcinoma.Neurology(R) neuroimmunology & neuroinflammation · 2024
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  15. Anti-Kelch-like protein 11 antibody encephalitis presenting with progressive cognitive deficits in an older woman: a case report and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 3 countries.

Alberto VogrigFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.ORCID https://orcid.org/0000-0002-3652-7061
Sarah PéricartDepartment of Pathology, CHU de Toulouse, IUC-Oncopole, 31300 Toulouse, France.
Anne-Laurie PintoFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.
Véronique RogemondFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.
Sergio Muñiz-CastrilloFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.
Géraldine PicardFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.
Marion SeltonDepartment of Neurology, CHRU Nancy, 54035 Nancy, France.
Michel MittelbronnLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch/Alzette, Luxembourg.
Hélène-Marie LanoiseléeDepartment of Neurology, CHR d'Orléans, 45100 Orléans, France.
Patrick MichenetDepartment of Pathology, CHR d'Orléans, 45100 Orléans, France.
Marie BenaiteauDepartment of Neurology, CHU de Toulouse, 31300 Toulouse, France.
Jérémie ParienteDepartment of Neurology, CHU de Toulouse, 31300 Toulouse, France.
Helene ZéphirUniversity of Lille, Inserm, CHU Lille, U1172 - Laboratory of neuroinflammation and Multiple Sclerosis, Lille Neuroscience & cognition, 59000 Lille, France.
Caroline GiordanaDepartment of Movement Disorders and Neurology, CHU Nice, 06003 Nice, France.
Solveig MontautDepartment of Neurology, CHRU de Strasbourg, 67091 Strasbourg, France.
Hayet SalhiCentre Expert Parkinson, Hôpital Henri-Mondor, AP-HP, 94010 Créteil, France.
Panagiotis BachoumasDepartment of Neurology, Centre Hospitalier Public du Cotentin, 50100 Cherbourg-en-Cotentin, France.
Alexis MontcuquetDepartment of Neurology, Dupuytren Hospital, 87000 Limoges, France.
Igor LetovanecInstitute of Pathology, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Emmanuelle Uro-CosteDepartment of Pathology, CHU de Toulouse, IUC-Oncopole, 31300 Toulouse, France.
Jérôme HonnoratFrench Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.ORCID https://orcid.org/0000-0002-4721-5952
Université Claude Bernard Lyon 1 · FRCentre Hospitalier Universitaire de Toulouse · FRCentre hospitalier universitaire d'Orléans · FRUniversité Toulouse III - Paul Sabatier · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Public du Cotentin · FRCentre Hospitalier Régional et Universitaire de Nancy · FRCentre Hospitalier Universitaire de Nice · FRHôpital Dupuytren · FRHôpitaux Universitaires de Strasbourg · FRInserm · FRUniversity of Lausanne · CHUniversity of Luxembourg · LU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report the clinical features of Kelch-like protein 11 antibody-associated paraneoplastic neurological syndrome, design and validate a clinical score to facilitate the identification of patients that should be tested for Kelch-like protein 11 antibodies, and examine in detail the nature of the immune response in both the brain and the tumour samples for a better characterization of the immunopathogenesis of this condition. The presence of Kelch-like protein 11 antibodies was retrospectively assessed in patients referred to the French Reference Center for paraneoplastic neurological syndrome and autoimmune encephalitis with (i) antibody-negative paraneoplastic neurological syndrome [limbic encephalitis (

Indexed as

antibodiesataxiaautoimmune encephalitisimmunopathologyparaneoplastic neurologic syndrome

Identifiers

PMID34557666
PMCPMC8453430
OpenAlexW3200562017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.