Evidence map›Paper›PMID 34557584›Full record

ArticleTransplantation direct2021

Living Donor Versus Deceased Donor Pediatric Liver Transplantation: A Systematic Review and Meta-analysis.

Arianna Barbetta, Chanté Butler, Sarah Barhouma, Rachel Hogen, Brittany Rocque, Cameron Goldbeck, Hannah Schilperoort, Glenda Meeberg, James Shapiro, Yong K Kwon and 2 more

Abstract read
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Financial toxicity in living donor liver transplantation: A call to action for financial neutrality.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  11. Review
  12. Diseases of bile duct in children.World journal of gastroenterology · 2024
    Review
  13. Review
  14. Outcome of split liver transplantationWorld journal of gastrointestinal surgery · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arianna BarbettaDepartment of Surgery, University of Southern California, Los Angeles, CA.
Chanté ButlerDepartment of Surgery, University of Southern California, Los Angeles, CA.
Sarah BarhoumaDepartment of Surgery, University of Southern California, Los Angeles, CA.
Rachel HogenDepartment of Surgery, University of Southern California, Los Angeles, CA.
Brittany RocqueDepartment of Surgery, University of Southern California, Los Angeles, CA.
Cameron GoldbeckDepartment of Surgery, University of Southern California, Los Angeles, CA.
Hannah SchilperoortWilson Dental Library, USC Libraries, University of Southern California, Los Angeles, CA.
Glenda MeebergDepartment of Surgery, University of Alberta, Edmonton, Canada.
James ShapiroDepartment of Surgery, University of Alberta, Edmonton, Canada.
Yong K KwonDepartment of Surgery, University of Southern California, Los Angeles, CA.
Rohit KohliDepartment of Pediatrics, University of Southern California, Los Angeles, CA.
Juliet EmamaulleeDepartment of Surgery, University of Southern California, Los Angeles, CA.

Funding

Immunologic Biomarkers of Rejection in Clinical Liver TransplantationK08CA245220 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EMAMAULLEE, JULIET · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA245220
6 · The paper itself

Abstract

Reduced-size deceased donors and living donor liver transplantation (LDLT) can address the organ shortage for pediatric liver transplant candidates, but concerns regarding technical challenges and the risk of complications using these grafts have been raised. The aim of this study was to compare outcomes for pediatric LDLT and deceased donor liver transplantation (DDLT) via systematic review.

methodsA systematic literature search was performed to identify studies reporting outcomes of pediatric (<18 y) LDLT and DDLT published between 2005 and 2019. A meta-analysis was conducted to examine peri- and postoperative outcomes using fixed- and random-effects models.

resultsOverall, 2518 abstracts were screened, and 10 studies met criteria for inclusion. In total, 1622 LDLT and 6326 DDLT pediatric patients from 4 continents were examined. LDLT resulted in superior patient survival when compared with DDLT at 1, 3, and 5 y post-LT (1-y hazard ratio: 0.58, 95% confidence interval [CI] 0.47-0.73,

conclusionsThis meta-analysis demonstrates that LDLT may offer many advantages when compared with DDLT in children and suggests that LDLT should continue to be expanded to optimize outcomes for pediatric LT candidates.

Identifiers

PMID34557584
PMCPMC8454909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.