Evidence map›Paper›PMID 34557423›Full record

ArticleFrontiers in cellular and infection microbiology2021

Early Leukocyte Responses in

Maria Adelaida Gomez, Ashton Trey Belew, Adriana Navas, Mariana Rosales-Chilama, Julieth Murillo, Laura A L Dillon, Theresa A Alexander, Alvaro Martinez-Valencia, Najib M El-Sayed

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Maria Adelaida GomezCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
Ashton Trey BelewDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, United States.
Adriana NavasCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
Mariana Rosales-ChilamaCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
Julieth MurilloCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
Laura A L DillonDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, United States.
Theresa A AlexanderDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, United States.
Alvaro Martinez-ValenciaCentro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.
Najib M El-SayedDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, United States.
Centro Internacional de Entrenamiento e Investigaciones Medicas · COUniversity of Maryland, College Park · USPontificia Universidad Javeriana · CO

Funding

The Innate Immune Response As A Therapeutic Target For Cutaneous LeishmaniasisU19AI129910 · NIAID · CENTRO INTERNACIONAL (CIDEIM) · PI GORE SARAVIA, NANCY · 2017 to 2021
$2.8M
NIAID NIH HHS U19 AI129910Wellcome TrustWellcome Trust 107595/Z/15/Z
6 · The paper itself

Abstract

Early host-pathogen interactions drive the host response and shape the outcome of natural infections caused by intracellular microorganisms. These interactions involve a number of immune and non-immune cells and tissues, along with an assortment of host and pathogen-derived molecules. Our current knowledge has been predominantly derived from research on the relationships between the pathogens and the invaded host cell(s), limiting our understanding of how microbes elicit and modulate immunological responses at the organismal level. In this study, we explored the early host determinants of healing and non-healing responses in human cutaneous leishmaniasis (CL) caused by

Indexed as

LeishmaniaLeishmania guyanensisLeishmaniasis, CutaneousHumansLeukocytesLeukocytes, Mononuclearhost-pathogen interactionsLeishmania ViannialeukocytesPBMCsRNA-Seq

Identifiers

PMID34557423
PMCPMC8453012
OpenAlexW3198082732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.