Evidence map›Paper›PMID 34557370›Full record

ArticleCureus2021

Secondary Hemophagocytic Lymphohistiocytosis in Post-COVID-19 Patients: A Report of Two Cases.

Pranjal Kalita, Devina Laishram, Biswajit Dey, Jaya Mishra, Bhupen Barman, Himesh Barman

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  7. Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pranjal KalitaPathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Devina LaishramPathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Biswajit DeyPathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Jaya MishraPathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Bhupen BarmanInternal Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Himesh BarmanPaediatrics, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a disease that can affect both children and adults. HLH can be categorized as primary or secondary. Secondary HLH (sHLH) may be secondary to various viral infections. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection is a pandemic with multi-system involvement. HLH in COVID-19 positive patients is a recognized entity. However, in post-COVID-19 patients who have recovered and are negative by serological tests and reverse transcription-polymerase chain reaction test may present with sHLH due to dysregulation of the immune system. We highlight this unusual finding of post-COVID-19 sHLH in two cases, who were diagnosed by the new revised H-score.

Indexed as

bone marrowcovid-19immune systemsars-cov-2secondary hemophagocytic lymphohistiocytosis

Identifiers

PMID34557370
PMCPMC8450015
OpenAlexW3195950269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.