Evidence map›Paper›PMID 34557310›Full record

ArticleRegenerative biomaterials2021

A pH-response chemotherapy synergistic photothermal therapy for tumor suppression and bone regeneration by mussel-inspired Mg implant.

Hongwei Shao, Shi Cheng, Mengyu Yao, Xiongfa Ji, Hua Zhong, Donghui Wang, Xiujuan Fan, Qian Li, Jielong Zhou, Yu Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Multifunctional Shape-Memory Polyurethane/MnOMaterials (Basel, Switzerland) · 2026
    Article
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  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Hongwei ShaoDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Shi ChengDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Mengyu YaoDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Xiongfa JiDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Hua ZhongDepartment of Orthopedics, The Fifth Affiliated Hospital of Southern Medical University, No. 566 Congcheng Avenue, Conghua District, Guangzhou, Guangdong 510900, China.
Donghui WangSchool of Materials Science and Engineering, Hebei University of Technology, No. 5340 Xiping Road, Beichen District, Tianjin 300130, China.
Xiujuan FanDepartment of Orthopedics, The Second School of Clinical Medicine, Southern Medical University, No. 111 Liuhua Road, Yuexiu District, Guangzhou, Guangdong 510515, China.
Qian LiDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Jielong ZhouDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Yu ZhangDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.
Feng PengDepartment of Orthopedics, Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong 510080, China.ORCID https://orcid.org/0000-0003-2366-2253
Guangdong Academy of Medical Sciences · CNGuangzhou University · CNGuangdong Academy of Sciences · CNHebei University of Technology · CNSouthern Medical University · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary malignant bone tumors can be life-threatening. Surgical resection of tumor plus chemotherapy is the standard clinical treatment. However, postoperative recovery is hindered due to tumor recurrence caused by residual tumor cells and bone defect caused by resection of tumor tissue. Herein, a multifunctional mussel-inspired film was fabricated on Mg alloy, that is, an inner hydrothermal-treated layer, a middle layer of polydopamine, and an outer layer of doxorubicin. The modified Mg alloy showed excellent photothermal effect and thermal/pH-controlled release of doxorubicin. The synergistic effect of chemotherapy and photothermal therapy enabled the modified Mg alloy to kill bone tumor

Indexed as

bone regenerationbone tumormagnesium alloysurface modification

Identifiers

PMID34557310
PMCPMC8455343
OpenAlexW3199147357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.