ReviewEvolution, medicine, and public health2021
Reinterpreting patterns of variation in human thyroid function: An evolutionary ecology perspective.
Review in Evolution, medicine, and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.).Journal of medical primatology · 2026Article
- Iodine deficiency in the first pregnancy trimester and intelligence in adolescence.European journal of nutrition · 2026Article
- Assessment of Thyroid Uptake Ratio Values in a Normal Population. Establishment of Normal Reference Values for 99mTc-Pertechnetate Thyroid Uptake in an Australian Population.Journal of medical radiation sciences · 2026Article
- Maternal thyroid function in the first half of pregnancy and neurodevelopmental outcomes in early adolescence in the Amsterdam Born Children and their Development (ABCD) cohort.Comprehensive psychoneuroendocrinology · 2026Article
- Comparison of thyroid hormones reference intervals based on thyroid antibody levels: A multicenter study.PloS one · 2026Article
- Public knowledge of thyroid disorders in the West Bank, Palestine: pregnancy and medication-related safety gaps in a cross-sectional study.Frontiers in public health · 2026Article
- Quality-of-Life Outcomes Following Thyroid Surgery in Pediatric Patients: A Systematic Review of Physical, Emotional, and Social Dimensions.Children (Basel, Switzerland) · 2025Review
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Mitochondrial function is enhanced by thyroid hormones during zebra finch development.Royal Society open science · 2024Article
- A systematic review on artificial intelligence techniques for detecting thyroid diseases.PeerJ. Computer science · 2023Article
- The Clinical Relevance of Hypothyroidism in Patients with Solid Non-Thyroid Cancer: A Tantalizing Conundrum.Journal of clinical medicine · 2022Review
- Thyroid Function at Age Fifty After Prenatal Famine Exposure in the Dutch Famine Birth Cohort.Frontiers in endocrinology · 2022Article
- The Intriguing Thyroid Hormones-Lung Cancer Association as Exemplification of the Thyroid Hormones-Cancer Association: Three Decades of Evolving Research.International journal of molecular sciences · 2021Review
- Thyroid Hormone Signalling in Human Evolution and Disease: A Novel Hypothesis.Journal of clinical medicine · 2021Review
- Review
- Improving the Quality of Life of Patients with an Underactive Thyroid Through mHealth: A Patient-Centered Approach.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Factors responsible for the persistence of Hypothyroidism among Pakistani Women.Pakistan journal of medical sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two hundred million people worldwide experience some form of thyroid disorder, with women being especially at risk. However, why human thyroid function varies between populations, individuals, and across the lifespan has attracted little research to date. This limits our ability to evaluate the conditions under which patterns of variation in thyroid function are best understood as 'normal' or 'pathological'. In this review, we aim to spark interest in research aimed at understanding the causes of variation in thyroid phenotypes. We start by assessing the biomedical literature on thyroid imbalance to discuss the validity of existing reference intervals for diagnosis and treatment across individuals and populations. We then propose an evolutionary ecological framework for understanding the phylogenetic, genetic, ecological, developmental, and physiological causes of normal variation in thyroid function. We build on this approach to suggest testable predictions for how environmental challenges interact with individual circumstances to influence the onset of thyroid disorders. We propose that dietary changes, ecological disruptions of co-evolutionary processes during pregnancy and with pathogens, emerging infections, and exacerbated stress responses can contribute to explaining the onset of thyroid diseases. For patients to receive the best personalized care, research into the causes of thyroid variation at multiple levels is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.