Evidence map›Paper›PMID 34557267›Full record

ArticleOxidative medicine and cellular longevity2021

Association of Low Molecular Weight Plasma Aminothiols with the Severity of Coronavirus Disease 2019.

Evgeny Vladimirovich Kryukov, Alexander Vladimirovich Ivanov, Vladimir Olegovich Karpov, Valery Vasil'evich Alexandrin, Alexander Mikhaylovich Dygai, Maria Petrovna Kruglova, Gennady Ivanovich Kostiuchenko, Sergei Petrovich Kazakov, Aslan Amirkhanovich Kubatiev

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Involvement of oxidative stress in post-acute sequelae of COVID-19: clinical implications.Redox report : communications in free radical research · 2025
    Article
  2. Article
  3. Review
  4. Persistent Post COVID-19 Endothelial Dysfunction and Oxidative Stress in Women.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Contribution of vitamin DScientific reports · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. COVID-19 and One-Carbon Metabolism.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Evgeny Vladimirovich KryukovBurdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, 105229 Moscow, Russia.ORCID https://orcid.org/0000-0002-8396-1936
Alexander Vladimirovich IvanovInstitute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.ORCID https://orcid.org/0000-0002-2424-6115
Vladimir Olegovich KarpovBurdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, 105229 Moscow, Russia.
Valery Vasil'evich AlexandrinInstitute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.
Alexander Mikhaylovich DygaiInstitute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.ORCID https://orcid.org/0000-0001-6286-5315
Maria Petrovna KruglovaFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Trubetskaya St., 8-2, 119991 Moscow, Russia.ORCID https://orcid.org/0000-0001-6939-160X
Gennady Ivanovich KostiuchenkoRegional Clinical Hospital, Lyapidevsky St., 1, 656024 Barnaul, Russia.
Sergei Petrovich KazakovBurdenko Main Military Clinical Hospital, Ministry of Defense, Gospitalnaya Sq., 3, 105229 Moscow, Russia.
Aslan Amirkhanovich KubatievInstitute of General Pathology and Pathophysiology, Baltiyskaya St., 8, 125315 Moscow, Russia.ORCID https://orcid.org/0000-0001-8077-2905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAminothiols (glutathione (GSH), cysteinylglycine (CG)) may play an important role in the pathogenesis of coronavirus disease 2019 (COVID-19), but the possible association of these indicators with the severity of COVID-19 has not yet been investigated.

methodsThe total content (

resultsLow tGSH level was associated with the risk of severe COVID-19 (tGSH ≤ 1.5

conclusionThus, tGSH and rCG can be seen as potential markers for the risk of severe COVID-19. GSH appears to be an important factor to oxidative damage prevention as infection progresses. This suggests the potential clinical efficacy of correcting glutathione metabolism as an adjunct therapy for COVID-19.

Indexed as

Advanced Oxidation Protein ProductsAgedAmino Acids, SulfurBiomarkersCOVID-19DipeptidesFemaleGlutathioneHumansLungMaleMiddle AgedOxidation-ReductionSARS-CoV-2Severity of Illness IndexAdvanced Oxidation Protein ProductsAmino Acids, SulfurBiomarkerscysteinylglycineDipeptidesGlutathione

Identifiers

PMID34557267
PMCPMC8455204

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.