Evidence map›Paper›PMID 34557234›Full record

ArticleIranian journal of parasitology

Efficacy of Novel Formulations of Ivermectin and Albendazole in Parasitic Infections of Sheep in the Altai Mountains of Russia.

Victor Alexeevich Marchenko, Salavat Samadovich Khalikov, Elena Alexandrovna Efremova, Mikhail Mikhaylovich Ilyin Ju

Open access · goldAbstract read
In one paragraph

Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Victor Alexeevich MarchenkoFederal Altai Scientific Center for Agrobiotechnology, Town 35, Barnaul, Russia.
Salavat Samadovich KhalikovA.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Science (RAS), Moscow, Russia.
Elena Alexandrovna EfremovaSiberian Federal Scientific Centre of Agro-Bio Technologies of the Russian Academy of Sciences, Krasnoobsk, Russia.
Mikhail Mikhaylovich Ilyin JuA.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Science (RAS), Moscow, Russia.
A. N. Nesmeyanov Institute of Organoelement Compounds · RUAltai Scientific Research Institute of Machine Building Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParasitic infections are widespread in sheep farms of the Russian Federation, including Siberia. The infection of sheep with helminths and parasitic arthropods with a range of 70% to 100% in different regions, contributes to a decrease in the productivity and quality of products, and even death of animals. This study aimed to formulate drugs with pronounced parasiticidal effects based on ivermectin and albendazole, widely used to treat animal entomoses and helminth infections.

methodsNew formulations in the form of solid dispersed compositions were prepared by mechanochemical modification of ivermectin and albendazole using arabinogalactan polysaccharide. The efficacy of preparations on gastrointestinal strongylosis and monieziosis, and melophagosis of sheep was determined by parasitological examination and analysis of feces and urine.

resultsThe new formulations demonstrated increased solubility and parasiticidal activity due to the formation of inclusion complexes when interact with water. The maximum efficacy values (> 95% efficiency) against intestinal Strongylida and

conclusionThe increased parasiticidal activity of innovative compositions can be explained by increased water solubility and bioavailability of the preparations, due to formation of inclusion complexes. The results of this study suggests the possibility of a significant reduction in the dosages of composed substances without losing their parasiticidal activity.

Indexed as

AlbendazoleArabinogalactanEfficacyIvermectinParasiticide

Identifiers

PMID34557234
PMCPMC8418662
OpenAlexW3166922678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.