Evidence map›Paper›PMID 34557187›Full record

ArticleFrontiers in immunology2021

Annexin A1 Mimetic Peptide Ac

Marcia Pereira Oliveira, Janesly Prates, Alexandre Dantas Gimenes, Silvia Graciela Correa, Sonia Maria Oliani

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. AcCells · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Marcia Pereira OliveiraLaboratory of Interdisciplinary Medical Research, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
Janesly PratesDepartment of Biology, Institute of Bioscience, Humanities and Exact Science, São Paulo State University (Unesp), São José do Rio Preto, Brazil.
Alexandre Dantas GimenesDepartment of Functional Morphology, Faceres School of Medicine, São José do Rio Preto, Brazil.
Silvia Graciela CorreaDepartamento de Bioquímica Clinica-Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI - CONICET) - Facultad de Ciencias Quimicas- Universidad Nacional de Córdoba (UNC), Córdoba, Argentina.
Sonia Maria OlianiDepartment of Biology, Institute of Bioscience, Humanities and Exact Science, São Paulo State University (Unesp), São José do Rio Preto, Brazil.
Universidade Estadual Paulista (Unesp) · BRConsejo Nacional de Investigaciones Científicas y Técnicas · ARFaculdade Ceres · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells (MCs) are main effector cells in allergic inflammation and after activation, they release stored (histamine, heparin, proteases) and newly synthesized (lipid mediators and cytokines) substances. In the gastrointestinal tract the largest MC population is located in the lamina propria and submucosa whereas several signals such as the cytokine IL-4, seem to increase the granule content and to stimulate a remarkable expansion of intestinal MCs. The broad range of MC-derived bioactive molecules may explain their involvement in many different allergic disorders of the gastrointestinal tract. Annexin A1 (AnxA1) is a 37 KDa glucocorticoid induced monomeric protein selectively distributed in certain tissues. Its activity can be reproduced by mimetic peptides of the N-terminal portion, such as Ac

Indexed as

AnimalsAnnexin A1Cell DegranulationCell LineColonCytokinesHumansInflammation MediatorsInterleukin-4MaleMast CellsMiceMice, Inbred C57BLMice, KnockoutPeptidesReceptors, Formyl PeptideAnnexin A1annexin A1 peptide (2-26)CytokinesIl4 protein, mouseInflammation MediatorsInterleukin-4PeptidesReceptors, Formyl Peptideannexin A1colon explant culturecompound 48/80FPRshuman MC line (HMC-1)IL-4mast cell (MC)

Identifiers

PMID34557187
PMCPMC8452975
OpenAlexW3198346793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.