Evidence map›Paper›PMID 34557025›Full record

ArticleInternational journal of general medicine2021

Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation.

Ahmed Salman, Mohamed Aon, Amr Hussein, Mohamed Salman, Mohamed Tourky, Ahmed Mahmoud, Feras Aljarad, Mohamed Elkaseer, Hossam El-Din Shaaban, Ahmed Moustafa and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-0026-0841
Mohamed AonInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0001-9109-1697
Amr HusseinInternal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed SalmanGeneral Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0001-5445-6415
Mohamed TourkyDepartment of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK.ORCID 0000-0002-4783-258X
Ahmed MahmoudSenior Clinical Fellow, Great Western Hospital NHS Foundation Trust, Swindon, UK.
Feras AljaradLewisham and Greenwich NHS Trust, Lewisham, London, UK.ORCID 0000-0002-8646-5815
Mohamed ElkaseerGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hossam El-Din ShaabanHepatology and Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.ORCID 0000-0002-0832-5382
Ahmed MoustafaDepartment of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0002-1687-7048
Ahmed El-MikkawyHepatology and Gastroenterology Department, Theodor Bilharz Research Institute, Cairo, Egypt.
Nahla GaballaAnesthesiology and Intensive Care Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt.
Heba AbdallahClinical Pathology Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt.
Zaky Ftouh Zaky RashedAnesthesiology and Intensive Care Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID 0000-0003-1853-1136
Hesham ElkassarInternal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University · EGAl-Azhar University · EGGreat Western Hospital · GBMenoufia University · EGAlfaisal University · SALewisham and Greenwich NHS Trust · GBNational Water Research Center · EGTheodor Bilharz Research Institute · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT).

methodsThis prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS).

resultsEuthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p<0.001) or the donor (p<0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS.

conclusionHypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation.

Indexed as

hepatocellular carcinomahypothyroidismliver transplantation

Identifiers

PMID34557025
PMCPMC8455075
OpenAlexW3198987702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.