ArticleDrug design, development and therapy2021
Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis.
Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Physicochemical Properties of Pineapple Stem Fiber/Gellan Gum Biocomposite Films as a Potential Platform for Buccal Drug Delivery.Journal of functional biomaterials · 2026Article
- Application and Potential of Local Drug Delivery Systems for Antibacterial Treatment of Periodontitis.International journal of molecular sciences · 2026Review
- Rational Design of Mechanically Optimized Hydrogels for Bone Tissue Engineering: A Review.Gels (Basel, Switzerland) · 2026Review
- Multifunctional Bilayer Wound Dressing Composed of Immediate Release Layer of Ofloxacin and Sustained Release Layer of Bergamot Oil.Pharmaceutics · 2025Article
- Characteristics, preparation and applicability in oral delivery systems of cellulose ether-based buccal films.Drug delivery · 2025Review
- Gellan gum-based composites hydrogel membranes with geranium and lemongrass oils for enhanced antibacterial and wound healing effect.Scientific reports · 2025Article
- Effect of Gellan Gum on the Properties of Collagen-HPMC Freeze-Dried Hydrogels for Mucosal Administration.Gels (Basel, Switzerland) · 2025Article
- Next-Generation Natural Hydrogels in Oral Tissue Engineering.Pharmaceutics · 2025Review
- Flaxseed Mucilage/Hydroxypropyl Methylcellulose and Sodium Alginate/Polyvinyl Alcohol Composite Bilayer Film as a Promising Drug Carrier for Periodontal Treatment.Turkish journal of pharmaceutical sciences · 2024Article
- Hypromellose-, Gelatin- and Gellan Gum-Based Gel Films with Chlorhexidine for Potential Application in Oral Inflammatory Diseases.Gels (Basel, Switzerland) · 2024Article
- Tunable Drug Release Rate Using Modular Oral Dosage Forms.Pharmaceutics · 2023Article
- Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds.Bioengineering & translational medicine · 2023Article
- Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth.Gels (Basel, Switzerland) · 2023Review
- In Vitro and In Vivo Characterisation of a Mucoadhesive Buccal Film Loaded with Doxycycline Hyclate for Topical Application in Periodontitis.Pharmaceutics · 2023Article
- Assessing the Synergistic Activity of Clarithromycin and Therapeutic Oils Encapsulated in Sodium Alginate Based Floating Microbeads.Microorganisms · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivePeriodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis.
methodsFilms were synthesized by double solvent casting technique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer.
resultsPrepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, folding endurance, swelling index, and mucoadhesive strength. Solid state characterization of formulation showed successful incorporation of drug and oil in separate layers of hydrogel structure. An in-vitro release study showed an initial burst release of drug followed by sustained release for up to 48 hours.
conclusionThe prepared mucoadhesive bilayer buccal films could be used as a potential therapeutic option for the management of periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.