Evidence map›Paper›PMID 34556948›Full record

ArticleAnnals of neurosciences2020

Sunday Yinka Olatunji, Iheanyichukwu Okoro, Joshua Oladele Owolabi, John Afees Olanrewaju, Stephen Taiye Adelodun, Sunday Oluseyi Fabiyi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Dysfunction of the Neurovascular Unit by Psychostimulant Drugs.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sunday Yinka OlatunjiDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Iheanyichukwu OkoroDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Joshua Oladele OwolabiDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
John Afees OlanrewajuDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.ORCID https://orcid.org/0000-0002-9540-4117
Stephen Taiye AdelodunDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Sunday Oluseyi FabiyiDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
Babcock University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPURPOSE: To evaluate the effects of 3,4-methylenedioxymethamphetamine (MDMA)-induced neuroinflammation on the pyramidal neurons and astrocytes of the cornu ammonis 1 (CA1) region of the hippocampus and the role of GK extract (GKE) in attenuating the effects in the rat model.

methodsThe study was carried out by using 60 healthy adult male Wistar rats, which were randomly assigned into six groups, A, B, C, D, E, and F (

resultsA significant reduction (

conclusionGKE has significant neuroprotective potential against MDMA-induced toxicity in brain tissue. This is evident in its prevention of MDMA-induced oxidative stress, pyramidal neuronal vacuolation, dispersion, and reactive astrogliosis in the CA1 region of the hippocampus. Our findings are dose-dependent, with 200 mg/kg of the extract being novel. We, however, recommend further study into the mechanism of action of GKE, on how it attenuates the astrocytic reaction caused by MDMA exposure.

Indexed as

astrocytesGarcinia kolahippocampusMDMAneuroinflammation

Identifiers

PMID34556948
PMCPMC8455002
OpenAlexW3121645043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.