Evidence map›Paper›PMID 34556862›Full record

ArticleNature chemical biology2021

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor.

Qiufeng Liu, Dehua Yang, Youwen Zhuang, Tristan I Croll, Xiaoqing Cai, Antao Dai, Xinheng He, Jia Duan, Wanchao Yin, Chenyu Ye and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Nature chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 96 citations in OpenAlex.

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  8. Review
  9. Cryo-EM structures of GnRHR: Foundations for next-generation therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  19. Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Qiufeng Liu *The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Dehua Yang *The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-3028-3243
Youwen Zhuang *The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Tristan I CrollDepartment of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Xiaoqing CaiThe National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Antao DaiThe National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Xinheng HeThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0001-7813-5480
Jia DuanThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wanchao YinThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-6889-4907
Chenyu YeSchool of Pharmacy, Fudan University, Shanghai, China.
Fulai ZhouThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-3840-6757
Beili WuThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-1936-0909
Qiang ZhaoUniversity of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0001-6251-6676
H Eric XuThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.ORCID http://orcid.org/0000-0002-6829-8144
Ming-Wei WangThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. mwwang@simm.ac.cn.
Yi JiangThe CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. yijiang@simm.ac.cn.ORCID http://orcid.org/0000-0002-0723-1413
Chinese Academy of Sciences · CNShanghai Institute of Materia Medica · CNFudan University · CNShanghai Medical College of Fudan University · CNShanghaiTech University · CNUniversity of Cambridge · GB

Funding

Wellcome Trust 209407Wellcome Trust 209407/Z/17/Z
6 · The paper itself

Abstract

Cholecystokinin A receptor (CCK

Indexed as

Amino Acid SequenceBenzodiazepinonesCholecystokininCryoelectron MicroscopyHumansLigandsModels, MolecularProtein BindingProtein ConformationProtein MultimerizationReceptor, Cholecystokinin AReceptors, G-Protein-CoupledSincalideTriazoles8-sulfocholecystokinin octapeptideBenzodiazepinonesCE-326597CholecystokininLigandsReceptor, Cholecystokinin AReceptors, G-Protein-CoupledSincalideTriazoles

Identifiers

PMID34556862
PMCPMC8604728
OpenAlexW3199344857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.