ArticleNature reviews. Gastroenterology & hepatology2021
Postbiotics - when simplification fails to clarify.
Registry-linked trialAbstract readLetterComment
In one paragraph
Article in Nature reviews. Gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06423001 (A Randomized, Cross-over, Placebo-Controlled, Double-Blind Clinical Trial on the Efficacy and Safety of Oral Administration of Postibiotic by FOS Fermentation From Lactobacillus Paracasei in the Treatment of Irritable Bowel Syndrome.), which is not on this map. Cited by 63 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Cross-over, Placebo-Controlled, Double-Blind Clinical Trial on the Efficacy and Safety of Oral Administration of Postibiotic by FOS Fermentation From Lactobacillus Paracasei in the Treatment of Irritable Bowel Syndrome.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- It's Dead! Can Postbiotics Really Help Performance and Recovery? A Systematic Review.Nutrients · 2024Pooled it
- Postbiotic Supplementation Increases Amino Acid Absorption from Plant-Based Meal: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study.Probiotics and antimicrobial proteins · 2025Trial
- Trial
- Postbiotics: An Overview and Recommendations for Improved Reporting.Molecular nutrition & food research · 2026Review
- Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut.Nature reviews. Gastroenterology & hepatology · 2026Review
- New Postbiotic Derived from Sequential Fermentation of TwoMicroorganisms · 2026Article
- Impact of Dietary Interventions withFoods (Basel, Switzerland) · 2026Article
- Gut microbiota dysbiosis in sepsis: mechanisms and the gut-organ axis with a focus on lung and brain interactions.Frontiers in microbiology · 2026Review
- OvercomingFrontiers in antibiotics · 2026Review
- The gut microbiota as a potential determinant of response to GLP-1 receptor agonists: a narrative review.Frontiers in endocrinology · 2026Review
- Gut Microbiota and Postbiotic Metabolites: Biotic Intervention for Enhancing Vaccine Responses and Personalized Medicine for Disease Prevention.Probiotics and antimicrobial proteins · 2026Review
- Health benefits of fermented foods: a strategic roadmap from the PIMENTO initiative.Frontiers in nutrition · 2026Review
- Potential role of postbiotics in supporting lean mass preservation and weight-loss sustainability during GLP-1-based anti-obesity therapy.Frontiers in nutrition · 2026Review
- Beyond breastfeeding: a One Health Decalogue for nurturing the infant microbiota.Frontiers in nutrition · 2026Review
- Proteomic Analysis of the Differential Response ofAntibiotics (Basel, Switzerland) · 2025Article
- Impact of Periodontal Host-Modulation Therapies on Oral-Gut Microbiome Axis in Periodontitis Patients with Hematological Diseases: A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Membrane vesicles produced by next-generation probiotics from the gut as innovative tools for human health.Gut microbes · 2025Review
- Postbiotics as microbial-derived therapeutics for wound healing disorders: from molecular mechanisms to future application.Cell communication and signaling : CCS · 2025Review
- Emerging Nonthermal Technologies for the Production of Postbiotics.Comprehensive reviews in food science and food safety · 2025Review
- Exploring the Potential Use of Probiotics, Prebiotics, Synbiotics, and Postbiotics as Adjuvants for Modulating the Vaginal Microbiome: a Bibliometric Review.Probiotics and antimicrobial proteins · 2025Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
38 authors.
José Eleazar Aguilar-ToaláLaboratory of Transformation and Emerging Technologies in Foods, National Autonomous University of Mexico, FES-Cuautitlan, Mexico.
Stefania ArioliDivision of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy.
Pradip BehareDairy Microbiology Division, ICAR-National Dairy Research Institute Karnal, Karnal, Haryana, India.ORCID http://orcid.org/0000-0002-0403-2398
Clara BelzerLaboratory of Microbiology, Wageningen University, Wageningen, Netherlands.
Roberto Berni CananiDepartment of Translational Medical Science, ImmunoNutritionLab at CEINGE Advanced Biotechnologies Research Center, European Laboratory for the Investigation of Food Induced Diseases, Task Force for Microbiome Studies - University of Naples "Federico II", Naples, Italy.ORCID http://orcid.org/0000-0002-5169-9574
Jean-Marc ChatelUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.
Enza D'AuriaAllergy Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.ORCID http://orcid.org/0000-0003-2750-5810
Mônica Queiroz de FreitasFaculty of Veterinary, Federal University Fluminense, Niterói, Brazil.
Eran ElinavImmunology department, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-5775-2110
Erick Almeida EsmerinoFaculty of Veterinary, Federal University Fluminense, Niterói, Brazil.
Hugo S GarcíaUnidad de Investigación y Desarrollo de Alimentos, TecMN-Instituto Tecnológico de Veracruz, Veracruz, Mexico.
Adriano Gomes da CruzDepartment of Food, Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
Aarón F González-CórdovaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C., Hermosillo, Mexico.
Simone GuglielmettiDivision of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. simone.guglielmetti@unimi.it.ORCID http://orcid.org/0000-0002-8673-8190
Jonas de Toledo GuimarãesFaculty of Veterinary, Federal University Fluminense, Niterói, Brazil.ORCID http://orcid.org/0000-0002-0414-6678
Adrián Hernández-MendozaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C., Hermosillo, Mexico.ORCID http://orcid.org/0000-0002-2360-7484
Philippe LangellaUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0001-5960-4341
Andrea M LiceagaDepartment of Food Science, Protein Chemistry & Bioactive Peptides Lab, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-0994-1205
Marciane MagnaniLaboratory of Microbial Processes in Foods, Department of Food Engineering, Federal University of Paraíba, João Pessoa, Brazil.
Rebeca MartinUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.
Mohammad Tamrin Mohamad LalBorneo Marine Research Institute, Universiti Malaysia Sabah, Sabah, Malaysia.
Diego MoraDivision of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy.
Mehran MoradiDepartment of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.ORCID http://orcid.org/0000-0002-6004-6874
Lorenzo MorelliDepartment for Sustainable Food Processes, Università Cattolica del Sacro Cuore, Piacenza, Italy. lorenzo.morelli@unicatt.it.
Fabio MoscaNeonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IRCCS), Milan, Italy.
Filomena NazzaroInstitute of Food Science - Italian National Research Council, Avellino, Italy.
Tatiana Colombo PimentelFederal Institute of Paraná, Campus Paranavaí, Paraná, Brazil.ORCID http://orcid.org/0000-0003-4600-8932
Chao RanKey Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.
Chaminda Senaka RanadheeraSchool of Agriculture & Food, Faculty of Veterinary & Agricultural Sciences, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-1367-7999
Maria RescignoIRCCS Humanitas Research Hospital, Milan, Italy. maria.rescigno@hunimed.eu.
Azucena SalasIDIBAPS, CIBEREHD, Barcelona, Spain.ORCID http://orcid.org/0000-0003-4572-2907
Anderson S Sant'AnaDepartment of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas, Campinas, Brazil.ORCID http://orcid.org/0000-0001-5052-2315
Katia SivieriDepartment of Biological Sciences, Faculty of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, Brazil.ORCID http://orcid.org/0000-0001-8632-1478
Harry SokolUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS UMR1319, Jouy-en-Josas, France.ORCID http://orcid.org/0000-0002-2914-1822
Valentina TavernitiDivision of Food Microbiology and Bioprocesses, Department of Food, Environmental and Nutritional Sciences, University of Milan, Milan, Italy. valentina.taverniti@unimi.it.
Belinda Vallejo-CordobaLaboratorio de Química y Biotecnología de Productos Lácteos, Centro de Investigación en Alimentación y Desarrollo A.C., Hermosillo, Mexico.
Jaroslav ZelenkaDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague, Czechia.ORCID http://orcid.org/0000-0001-8145-8037
Zhigang ZhouChina-Norway Joint Lab on Fish Gastrointestinal Microbiota, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing, China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
ProbioticsHumans
Identifiers
PMID
34556825What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06423001ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.