ArticleThe ISME journal2022
Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 31 citations in OpenAlex.
- Heterotrophic bacterial bioleaching and sequestration of uranium from mineral resources: a review.Frontiers in microbiology · 2026Review
- A small periplasmic protein governs broad physiological adaptations in Vibrio cholerae via regulation of the DbfRS two-component system.Nature communications · 2025Article
- Exploring functional microbiota for uranium sequestration in Zoige uranium mine soil.Microbiology spectrum · 2025Article
- Rare earth elements in biology: From biochemical curiosity to solutions for extractive industries.Microbial biotechnology · 2024Review
- Impact of microbial processes on the safety of deep geological repositories for radioactive waste.Frontiers in microbiology · 2023Review
- A critical review of mineral-microbe interaction and co-evolution: mechanisms and applications.National science review · 2022Review
- Effect of different phosphate sources on uranium biomineralization by theFrontiers in microbiology · 2022Article
- Molecular Mechanisms Underlying Bacterial Uranium Resistance.Frontiers in microbiology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uranium is a naturally occurring radionuclide. Its redistribution, primarily due to human activities, can have adverse effects on human and non-human biota, which poses environmental concerns. The molecular mechanisms of uranium tolerance and the cellular response induced by uranium exposure in bacteria are not yet fully understood. Here, we carried out a comparative analysis of four actinobacterial strains isolated from metal and radionuclide-rich soils that display contrasted uranium tolerance phenotypes. Comparative proteogenomics showed that uranyl exposure affects 39-47% of the total proteins, with an impact on phosphate and iron metabolisms and membrane proteins. This approach highlighted a protein of unknown function, named UipA, that is specific to the uranium-tolerant strains and that had the highest positive fold-change upon uranium exposure. UipA is a single-pass transmembrane protein and its large C-terminal soluble domain displayed a specific, nanomolar binding affinity for UO
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Registered trials
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