ArticleCommunications biology2021
Real-time synthesis of imagined speech processes from minimally invasive recordings of neural activity.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial intelligence for brain-to-speech decoding in paralysis: a systematic review.BMC medical informatics and decision making · 2026Pooled it
- Real-time detection of spoken speech from unlabeled ECoG signals: a pilot study with an ALS participant.Journal of neural engineering · 2025Trial
- Temporally structured motor and auditory representations in covert syllable production.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Imagined Speech Brain-Computer Interface: A Task-Oriented Review of Neural Decoding.Sensors (Basel, Switzerland) · 2026Review
- Encoding of speech modes and loudness in ventral precentral gyrus.Nature communications · 2026Article
- Distributed cortico-subcortical networks enable robust speech state detection from sparse intracranial recordings.Frontiers in neuroscience · 2026Article
- Soft Multiaxial Strain Mapping Interface with AI-Driven Decoding for Silent Speech in Noise.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Clinical evaluation of communication brain computer interfaces in amyotrophic lateral sclerosis: a landscape analysis.Frontiers in human neuroscience · 2026Article
- Revealing spatiotemporal neural activation patterns in electrocorticography recordings of human speech production by mutual information.Neuroscience informatics · 2025Article
- Transfer learning via distributed brain recordings enables reliable speech decoding.Nature communications · 2025Article
- Mimed speech as an intermediary state between overt and imagined speech production in an electrocorticography study.Scientific reports · 2025Article
- Progress, challenges and future of linguistic neural decoding with deep learning.Communications biology · 2025Review
- Article
- An instantaneous voice-synthesis neuroprosthesis.Nature · 2025Article
- Encoding of speech modes and loudness in ventral precentral gyrus.bioRxiv : the preprint server for biology · 2025Article
- VocalMind: A Stereotactic EEG Dataset for Vocalized, Mimed, and Imagined Speech in Tonal Language.Scientific data · 2025Article
- A streaming brain-to-voice neuroprosthesis to restore naturalistic communication.Nature neuroscience · 2025Article
- Invasive Brain-Computer Interface for Communication: A Scoping Review.Brain sciences · 2025Review
- Whole-brain dynamics of articulatory, acoustic and semantic speech representations.Communications biology · 2025Article
- Learning to operate an imagined speech Brain-Computer Interface involves the spatial and frequency tuning of neural activity.Communications biology · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Speech neuroprosthetics aim to provide a natural communication channel to individuals who are unable to speak due to physical or neurological impairments. Real-time synthesis of acoustic speech directly from measured neural activity could enable natural conversations and notably improve quality of life, particularly for individuals who have severely limited means of communication. Recent advances in decoding approaches have led to high quality reconstructions of acoustic speech from invasively measured neural activity. However, most prior research utilizes data collected during open-loop experiments of articulated speech, which might not directly translate to imagined speech processes. Here, we present an approach that synthesizes audible speech in real-time for both imagined and whispered speech conditions. Using a participant implanted with stereotactic depth electrodes, we were able to reliably generate audible speech in real-time. The decoding models rely predominately on frontal activity suggesting that speech processes have similar representations when vocalized, whispered, or imagined. While reconstructed audio is not yet intelligible, our real-time synthesis approach represents an essential step towards investigating how patients will learn to operate a closed-loop speech neuroprosthesis based on imagined speech.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.