Observational studyScientific reports2021
Non-invasively measured brain activity and radiological progression in diffuse glioma.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions.Neuro-oncology advances · 2026Review
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Electrophysiology of gliomas: current science, implications, and opportunities.Frontiers in oncology · 2025Review
- Self-selected versus imposed running intensity and the acute effects on mood, cognition, and (a)periodic brain activity.Cognitive neurodynamics · 2024Article
- Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells.Nature medicine · 2024Article
- Patient-Centered Management of Brain Tumor-Related Epilepsy.Current neurology and neuroscience reports · 2024Review
- Symptom networks in glioma patients: understanding the multidimensionality of symptoms and quality of life.Journal of cancer survivorship : research and practice · 2024Article
- The relationship between pathological brain activity and functional network connectivity in glioma patients.Journal of neuro-oncology · 2024Article
- Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management.Neuro-oncology · 2024Review
- Multiscale network neuroscience in neuro-oncology: How tumors, brain networks, and behavior connect across scales.Neuro-oncology practice · 2023Review
- Article
- Recapitulating the Key Advances in the Diagnosis and Prognosis of High-Grade Gliomas: Second Half of 2021 Update.International journal of molecular sciences · 2023Review
- Remote neuronal activity drives glioma infiltration via Sema4f.bioRxiv : the preprint server for biology · 2023Article
- Regional healthy brain activity, glioma occurrence and symptomatology.Brain : a journal of neurology · 2022Article
- Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma.Journal of neuro-oncology · 2022Observational
- The relationship between deviant brain activity and executive functioning in glioma patients.Neuro-oncology advancesArticle
- Investigation of neurophysiologic and functional connectivity changes following glioma resection using magnetoencephalography.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoencephalography (MEG) was recorded in 45 diffuse glioma patients. Brain activity was estimated using three measures (absolute broadband power, offset and slope) calculated at three spatial levels: global average, averaged across the peritumoral areas, and averaged across the homologues of these peritumoral areas in the contralateral hemisphere. Tumors were segmented on MRI. Changes in tumor volume between the two scans surrounding the MEG were calculated and correlated with brain activity. Brain activity was compared between patient groups classified into having increasing or stable tumor volume. Results show that brain activity was significantly increased in the tumor hemisphere in general, and in peritumoral regions specifically. However, none of the measures and spatial levels of brain activity correlated with changes in tumor volume, nor did they differ between patients with increasing versus stable tumor volumes. Longitudinal studies in more homogeneous subgroups of glioma patients are necessary to further explore the clinical potential of non-invasively measured brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.