ArticleNPJ biofilms and microbiomes2021
Periodontitis associates with species-specific gene expression of the oral microbiota.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microbial signatures in human periodontal disease: a metatranscriptome meta-analysis.Frontiers in microbiology · 2024Pooled it
- Probiotics Augment the Effect of Non-Surgical Periodontal Treatment-A Randomised, Double-Blinded, Placebo-Controlled Trial.Journal of clinical periodontology · 2026Trial
- Probiotics alleviate oral microbiota disruptions induced byFrontiers in cellular and infection microbiology · 2026Trial
- Exploring the Oral Resistome: From Metagenomics to Precision Oral Health.Microorganisms · 2026Review
- Beyond the canonical view: steroid receptor network plasticity and mechanosensitive chromatin integration in breast cancer.NAR cancer · 2026Review
- Article
- Micro/Nanoplastics and Periodontitis: An Environmental Microbiology Perspective on Oral Retention and Systemic Risk.Microorganisms · 2026Review
- Article
- The Interplay Between Periodontitis and Atrial Fibrillation: Inflammation as a Common Pathophysiological Bridge.International journal of molecular sciences · 2026Review
- Oral Microbiota and Type 2 Diabetes: Interactions, Potential Mechanisms, and Preventive Strategies.Microorganisms · 2026Review
- Microbial Profiling of Saliva, Oral Rinse, Subgingival Plaque and GCF Reveals Site-Specific Dysbiosis in Periodontitis: A Within-Subject Comparison of 150 Participants.Journal of clinical periodontology · 2026Article
- Metagenome-based virome analysis identifies the oral viral signatures for periodontitis.Journal of oral microbiology · 2026Article
- Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro-Inflammatory M1 Macrophage Polarization in Periodontitis.Mediators of inflammation · 2026Article
- Article
- Sex-specific variations in subgingival microbiome of elderly patients with moderate periodontitis: an exploratory study.Frontiers in genetics · 2026Article
- Article
- Oral and fecal microbiota in Chinese adults with obesity reveal potential niche-specific microbiota associated with obesity.BMC microbiology · 2025Article
- Identification of Bacterial Networks and Relationship to Host Responses in Early Periodontitis Population over 24 Months.International journal of molecular sciences · 2025Article
- Exploring the plausible genetic relationship of salivary and tongue microbiome with periodontitis: A mendelian randomization study.The Saudi dental journal · 2025Article
- Oral Microbiome Signatures in Periodontitis and Edentulism-A Population-Based Study.Journal of periodontal research · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the present investigation was to characterize species-specific bacterial activity of the oral microbiota in periodontitis. We tested the hypotheses that chronic inflammation, i.e., periodontitis, associates with bacterial gene expression of the oral microbiota. Oral microbial samples were collected from three oral sites-subgingival plaque, tongue, and saliva from patients with periodontitis and healthy controls. Paired metagenomics and metatranscriptomics were used to perform concomitant characterization of taxonomic composition and to determine species-specific bacterial activity as expressed by the ratio of specific messenger RNA reads to their corresponding genomic DNA reads. Here, we show the association of periodontitis with bacterial gene expression of the oral microbiota. While oral site was the main determinant of taxonomic composition as well as bacterial gene expression, periodontitis was significantly associated with a reduction of carbohydrate metabolism of the oral microbiota at three oral sites (subgingival plaque, tongue, and saliva). Data from the present study revealed the association of periodontitis with bacterial gene expression of the oral microbiota. Conditions of periodontitis was associated with bacterial activity of local subgingival plaque, but also on tongue and the salivary microbiota. Collectively, data suggest that periodontitis associates with impaired carbohydrate metabolism of the oral microbiota. Future longitudinal and interventional studies are warranted to evaluate the potential pathogenic role of impaired bacterial carbohydrate metabolism not only in periodontitis but also in other diseases with low-grade inflammation, such as type 2 diabetes mellitus.
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