Trial reportNature communications2021
Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.
Trial report in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174875 (Developmental Pathways to Health and Disease), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Pathways to Health and Disease: Metabolic, Neurodevelopmental and Related Outcomes
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Infertility treatment and offspring blood pressure-a systematic review and meta-analysis.Human reproduction update · 2025Pooled it
- Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis.European heart journal · 2023Pooled it
- Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood.JAMA network open · 2022Pooled it
- Analyses of child cardiometabolic phenotype following assisted reproductive technologies using a pragmatic trial emulation approach.Nature communications · 2021Trial
- Effects of assisted reproductive techniques on offspring cardiovascular health: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- REFINE2: a simplified simulation tool to help epidemiologists evaluate the suitability and sensitivity of effect estimation within user-specified data.American journal of epidemiology · 2026Article
- How Early-Life Programming During Embryogenesis Imprints Cellular Memory.International journal of molecular sciences · 2025Review
- Chloroquine mitigates long-term effects of in vitro culture in mouse embryos.Frontiers in cell and developmental biology · 2025Article
- Article
- Learning across diverse biomedical data modalities and cohorts: Challenges and opportunities for innovation.Patterns (New York, N.Y.) · 2024Review
- Trajectories of lifestyle patterns from 2 to 8 years of age and cardiometabolic risk in children: the GUSTO study.The international journal of behavioral nutrition and physical activity · 2024Article
- Exposure to perfluoroalkyl substances and women's fertility outcomes in a Singaporean population-based preconception cohort.The Science of the total environment · 2023Article
- Study protocol for a Developmental Epidemiological Study of Children born through Reproductive Technologies (DESCRT).Human reproduction open · 2023Review
- Epigenetic Risks of Medically Assisted Reproduction.Journal of clinical medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 5 countries.
Funding
Abstract
Assisted reproductive technologies (ART) are increasingly used, however little is known about the long-term health of ART-conceived offspring. Weak selection of comparison groups and poorly characterized mechanisms impede current understanding. In a prospective cohort (Growing Up in Singapore Towards healthy Outcomes; GUSTO; Clinical Trials ID: NCT01174875) including 83 ART-conceived and 1095 spontaneously-conceived singletons, we estimate effects of ART on anthropometry, blood pressure, serum metabolic biomarkers, and cord tissue DNA methylation by emulating a pragmatic trial supported by machine learning-based estimators. We find ART-conceived children to be shorter (-0.5 SD [95% CI: -0.7, -0.2]), lighter (-0.6 SD [-0.9, -0.3]) and have lower skinfold thicknesses (e.g. -14% [-24%, -3%] suprailiac), and blood pressure (-3 mmHg [-6, -0.5] systolic) at 6-6.5 years, with no strong differences in metabolic biomarkers. Differences are not explained by parental anthropometry or comorbidities, polygenic risk score, breastfeeding, or illnesses. Our simulations demonstrate ART is strongly associated with lower NECAB3 DNA methylation, with negative control analyses suggesting these estimates are unbiased. However, methylation changes do not appear to mediate observed differences in child phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.