Evidence map›Paper›PMID 34556523›Full record

ArticleMolecular cancer research : MCR2022

Mutations in Noncoding

Samah El Ghamrasni, Rene Quevedo, James Hawley, Parisa Mazrooei, Youstina Hanna, Iulia Cirlan, Helen Zhu, Jeff P Bruce, Leslie E Oldfield, S Y Cindy Yang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Samah El GhamrasniPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-4346-1360
Rene QuevedoPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
James HawleyPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-4744-5552
Parisa MazrooeiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Youstina HannaPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Iulia CirlanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-1186-5435
Helen ZhuPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Jeff P BrucePrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0001-5509-9990
Leslie E OldfieldPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
S Y Cindy YangPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Paul GuilhamonDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-8276-5987
Jüri ReimandDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Dave W CesconPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-1080-0998
Susan J DonePrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-1770-988X
Mathieu LupienPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. trevor.pugh@utoronto.ca mlupien@uhnresearch.ca.
Trevor J PughPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. trevor.pugh@utoronto.ca mlupien@uhnresearch.ca.ORCID 0000-0002-8073-5888
University Health Network · CAOntario Institute for Cancer Research · CAHospital for Sick Children · CA

Funding

CIHR 136963CIHR 158225CIHR 168933
6 · The paper itself

Abstract

Whole-genome sequencing of primary breast tumors enabled the identification of cancer driver genes and noncoding cancer driver plexuses from somatic mutations. However, differentiating driver from passenger events among noncoding genetic variants remains a challenge. Herein, we reveal cancer-driver

Indexed as

Breast NeoplasmsChromatinFemaleGene Expression Regulation, NeoplasticHumansMutationWhole Genome SequencingChromatin

Identifiers

PMID34556523
PMCPMC9398156
OpenAlexW3199609442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.