Evidence map›Paper›PMID 34556492›Full record

ArticleBMJ open respiratory research2021

Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).

Jim M Wild, Joanna C Porter, Philip L Molyneaux, Peter M George, Iain Stewart, Richard James Allen, Raminder Aul, John Kenneth Baillie, Shaney L Barratt, Paul Beirne and 44 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. LongitudinalJournal of magnetic resonance imaging : JMRI · 2026
    Article
  3. COVID-19 and Interstitial Lung Disease.Medicina (Kaunas, Lithuania) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. CT findings in "Post-Covid": residua from acute pneumonia or "Post-Covid-ILD"?Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023
    Article
  11. Post-COVID Interstitial Lung Disease-The Tip of the Iceberg.Immunology and allergy clinics of North America · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Diffuse Lung Disease in Convalescents of COVID-19.Herald of the Russian Academy of Sciences · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 1 country.

Jim M WildDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
Joanna C PorterCentre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK.
Philip L MolyneauxNational Heart and Lung Institute, Imperial College London, London, UK.
Peter M GeorgeNational Heart and Lung Institute, Imperial College London, London, UK.
Iain StewartNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-1340-2688
Richard James AllenDepartment of Health Sciences, University of Leicester, Leicester, UK.
Raminder AulRespiratory Medicine, St George's Hospital NHS Foundation Trust, London, UK.
John Kenneth BaillieRoslin Institute, University of Edinburgh, Midlothian, UK.ORCID 0000-0001-5258-793X
Shaney L BarrattBristol Interstitial Lung Diseases Service, North Bristol NHS Trust, Bristol, UK.
Paul BeirneRespiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Stephen M BianchiAcademic Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
John F BlaikleyManchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.
Jonathan BrookeDepartment of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Nazia ChaudhuriFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID 0000-0003-3325-6996
Guilhem CollierDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
Emma K DennenyCentre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-7695-325X
Annemarie DochertyCentre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Laura FabbriNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-8250-6464
Michael A GibbonsRespiratory Medicine, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Fergus V GleesonDepartment of Oncology, University of Oxford, Oxford, UK.
Bibek GooptuDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Ian P HallNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Neil A HanleyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Melissa HeightmanRespiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK.
Toby E HillmanRespiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK.
Simon R JohnsonNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-9837-2763
Mark G JonesClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Fasihul KhanNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.ORCID 0000-0002-0796-5724
Rod LawsonAcademic Department of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Puja MehtaCentre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK.
Jane A MitchellNational Heart and Lung Institute, Imperial College London, London, UK.
Manuela PlatéCentre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-9957-0681
Krisnah PoinasamyHead of Research and Innovation Advocacy, Asthma UK, London, UK.
Jennifer K QuintNational Heart and Lung Institute, Imperial College London, London, UK.
Pilar Rivera-OrtegaRespiratory Department, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Malcolm SempleChild Health, University of Liverpool, Liverpool, UK.
A John SimpsonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Djf SmithNational Heart and Lung Institute, Imperial College London, London, UK.
Mark SpearsRespiratory Medicine, Perth Royal Infirmary, NHS Tayside, Perth, UK.
LIsa G SpencerRespiratory Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Stefan C StanelRespiratory Department, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.ORCID 0000-0001-9718-2952
David R ThickettBirmingham Acute Care Research Group, University of Birmingham, Birmingham, UK.
A A Roger ThompsonDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
Simon Lf WalshNational Heart and Lung Institute, Imperial College London, London, UK.
Nicholas D WeatherleyDepartment of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.ORCID 0000-0001-5589-2219
Mark Everard WeeksNational Heart and Lung Institute, Imperial College London, London, UK.
Dan G WoottonRespiratory Medicine, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Chris E BrightlingInstitute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-5803-5121
Rachel C ChambersCentre for Inflammation and Tissue Repair, UCL Respiratory, University College London, London, UK.ORCID 0000-0003-1370-9417
Ling-Pei HoMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine Oncology, Oxford, UK.
Joseph JacobDepartment of Respiratory Medicine, University College London, London, UK.
Karen Piper HanleyDivision of Diabetes, Endocrinology & Gastroenterology, The University of Manchester, Manchester, UK.
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, UK.
R Gisli JenkinsNational Heart and Lung Institute, Imperial College London, London, UK gisli.jenkins@imperial.ac.uk.ORCID 0000-0002-7929-2119
Imperial College London · GBGuy's and St Thomas' NHS Foundation Trust · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Leicester · GBUniversity of Manchester · GBUniversity of Sheffield · GBUniversity of Liverpool · GBUniversity of Nottingham · GBCentre for Inflammation Research · GBSheffield Teaching Hospitals NHS Foundation Trust · GBAsthma UK · GBChurchill Hospital · GBLeeds Teaching Hospitals NHS Trust · GBLondon Chest Hospital · GBManchester Academic Health Science Centre · GBManchester University NHS Foundation Trust · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBNorth Bristol NHS Trust · GBNottingham University Hospitals NHS Trust · GBRoslin Institute · GB

Funding

British Heart Foundation FS/18/13/33281British Heart Foundation SP/14/6/31350Medical Research Council G1000861Medical Research Council MC_PC_19025Medical Research Council MC_PC_19059Medical Research Council MC_PC_20022Medical Research Council MR/M008894/1Medical Research Council MR/S019669/1Medical Research Council MR/T032529/1Medical Research Council MR/V027859/1Medical Research Council MR/W006111/1
6 · The paper itself

Abstract

introductionThe COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD). METHODS AND ANALYSIS: The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment. ETHICS AND DISSEMINATION: All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals.

conclusionThis study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.

Indexed as

Lung Diseases, InterstitialCOVID-19HumansLongitudinal StudiesObservational Studies as TopicPandemicsPost-Acute COVID-19 SyndromeProspective StudiesUnited KingdombronchoscopyCOVID-19interstitial fibrosis

Identifiers

PMID34556492
PMCPMC8461362
OpenAlexW3200907194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.